MECP2 binds NOTCH1 gene promoter

Stable Identifier
R-HSA-9023346
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MECP2 binds NOTCH1 gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, MECP2 binds the promoter of the NOTCH1 gene. Binding of MECP2 to the NOTCH1 gene promoter is inhibited by AURKB-mediated phosphorylation of MECP2 at serine residue S423 (Li et al. 2014).
Participants
Input
Output
Participates
as an event of
Inferred From
Mecp2 binds Notch1 gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-27)
Cite Us!