MECP2 mRNA translation is inhibited by miR-132

Stable Identifier
R-HSA-9021183
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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MECP2 mRNA translation is inhibited by miR-132
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Based on studies in mice and rats, miR-132 reduces both mRNA and protein levels of MECP2. miR-132 is therefore expected to function in the context of the endonucleolytic RISC, and possibly also non-endonucleolytic RISC. MicroRNA miR-132 is complementary to the 3'UTR of long MECP2 transcripts (>10 kb), which are predominantly expressed in the brain (Klein et al. 2007, Su et al. 2015). Based on sequence similarity, human MECP2 mRNA is also predicted to be a miR-132 target.
Literature References
PubMed ID Title Journal Year
17994015 Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Impey, S, Mandel, G, Lioy, DT, Klein, ME, Goodman, RH, Ma, L

Nat. Neurosci. 2007
26239616 MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression

Zhao, Y, Su, M, Hong, J, Liu, S, Xue, X

Mol Med Rep 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
MECP2 mRNA:miR-132 RISC [cytosol] (Homo sapiens)
Active Unit
miR-132 RISC [cytosol]
Inferred From
Mecp2 mRNA translation is inhibited by miR-132 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-15)
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