MECP2 mRNA translation is inhibited by miR-132

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R-HSA-9021183
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Reaction [omitted]
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Homo sapiens
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Based on studies in mice and rats, miR-132 reduces both mRNA and protein levels of MECP2. miR-132 is therefore expected to function in the context of the endonucleolytic RISC, and possibly also non-endonucleolytic RISC. MicroRNA miR-132 is complementary to the 3'UTR of long MECP2 transcripts (>10 kb), which are predominantly expressed in the brain (Klein et al. 2007, Su et al. 2015). Based on sequence similarity, human MECP2 mRNA is also predicted to be a miR-132 target.

Literature References
PubMed ID Title Journal Year
26239616 MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression

Su, M, Hong, J, Zhao, Y, Liu, S, Xue, X

Mol Med Rep 2015
17994015 Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA

Klein, ME, Lioy, DT, Ma, L, Impey, S, Mandel, G, Goodman, RH

Nat. Neurosci. 2007
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