Reactome | ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3

ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3

Stable Identifier

R-HSA-9020610

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ALOX15 oxidises 18(S)-HEPE to 18(S)-RvE3

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Unlike resolvins E1 and E2, both of which are biosynthesised by neutrophils via the 5-lipoxygenase pathway, resolvin E3 (RvE3) is biosynthesised in eosinophils or resident macrophages via the 15-lipoxygenase (ALOX15) pathway. 18(S)-hydroxyeicosapentaenoic acid (18(S)-HEPE) is oxidised by ALOX15 (possibly through C13-hydrogen abstraction) into a number of dihydroxy-HEPEs including 17(R),18(S)-diHEPE (18(S)-RvE3) (Isobe et al. 2012, Isobe et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23293324	Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3 Arita, M, Masuda, K, Todoroki, H, Iwamoto, R, Arai, H, Inoue, M, Urabe, D, Isobe, Y	J. Biochem.	2013
22275352	Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid Arita, M, Sasaki, K, Matsueda, S, Masuda, K, Taguchi, R, Fujihara, T, Iwamoto, R, Arai, H, Inoue, M, Urabe, D, Nakanishi, H, Isobe, Y	J. Biol. Chem.	2012