LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1

Stable Identifier
R-HSA-9020257
Type
Reaction [transition]
Species
Homo sapiens
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H may also be able to catalyse the hydrolysis of 17R(6)-epoxy-docosahexaenoic acid (17R(16)-epoxy-DHA) to 10(R),17(R)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid (aspirin-triggered (neuro)protectin D1, AT-(N)PD1) (Serhan et al. 2011). In human cells, AT-(N)PD1 decreased PMN migration as well as enhancing efferocytosis of apoptotic human PMN by macrophages, indicating AT-(N)PD1 as a potent anti-inflammatory proresolving molecule (Serhan et al. 2011).

Literature References
PubMed ID Title Journal Year
21867913 Novel proresolving aspirin-triggered DHA pathway

Serhan, CN, Fredman, G, Yang, R, Karamnov, S, Belayev, LS, Bazan, NG, Zhu, M, Winkler, JW, Petasis, NA

Chem. Biol. 2011
Participants
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Catalyst Activity
Title
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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