Reactome | LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1

LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1

Stable Identifier

R-HSA-9020257

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1

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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H may also be able to catalyse the hydrolysis of 17R(6)-epoxy-docosahexaenoic acid (17R(16)-epoxy-DHA) to 10(R),17(R)-dihydroxydocosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid (aspirin-triggered (neuro)protectin D1, AT-(N)PD1) (Serhan et al. 2011). In human cells, AT-(N)PD1 decreased PMN migration as well as enhancing efferocytosis of apoptotic human PMN by macrophages, indicating AT-(N)PD1 as a potent anti-inflammatory proresolving molecule (Serhan et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21867913	Novel proresolving aspirin-triggered DHA pathway Zhu, M, Serhan, CN, Winkler, JW, Petasis, NA, Bazan, NG, Fredman, G, Karamnov, S, Yang, R, Belayev, LS	Chem. Biol.	2011