LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4

Stable Identifier
R-HSA-9020253
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 4S(5)-epoxy-17(S)-hydroxydocosahexaenoic acid (4S(5)-epoxy-17(S)-HDHA) to the trihydroxydocosahexaenoic acids 4(S), 11(R), 17(S)-triHDHA and 4(S), 5(R), 17(S)-triHDHA (RvD3 and RvD4 respectively) (Dalli et al. 2013, Serhan et al. 2002, Winkler et al. 2013, 2016). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

Literature References
PubMed ID Title Journal Year
28980694 Stereocontrolled synthesis and investigation of the biosynthetic transformations of 16(S),17(S)-epoxy-PDn-3 DPA

Primdahl, KG, Tungen, JE, De Souza, PRS, Colas, RA, Dalli, J, Hansen, TV, Vik, A

Org. Biomol. Chem. 2017
26743932 Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

Winkler, JW, Orr, SK, Dalli, J, Cheng, CY, Sanger, JM, Chiang, N, Petasis, NA, Serhan, CN

Sci Rep 2016
23438748 Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents

Dalli, J, Winkler, JW, Colas, RA, Arnardottir, H, Cheng, CY, Chiang, N, Petasis, NA, Serhan, CN

Chem. Biol. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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