LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2

Stable Identifier
Reaction [transition]
Homo sapiens
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Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(R)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(R)-triHDHA and 7(S), 16(R), 17(R)-triHDHA (AT-RvD1 and AT-RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).

Literature References
PubMed ID Title Journal Year
19865173 Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

Cooper, D, Serhan, CN, Spite, M, Perretti, M, Petasis, NA, Flower, RJ, Yang, R, Summers, L, Norling, LV

Nature 2009
17244615 Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation

Serhan, CN, Campbell, E, Colgan, SP, Oh, SF, Petasis, NA, Gotlinger, K, Yang, R, Uddin, J, Sun, YP

J. Biol. Chem. 2007
12391014 Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals

Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL

J. Exp. Med. 2002
Catalyst Activity

epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]

Orthologous Events
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