Leukotriene A4 hydrolase (LTA4H) is a monomeric, soluble enzyme that uses a Zn2+ cofactor to catalyse the hydrolysis of the allylic epoxide leukotriene A4 (LTA4) (McGee & Fitzpatrick 1985). LTA4H can also catalyse the hydrolysis of 7S(8)-epoxy-17(R)-hydroxydocosahexaenoic acid (7S(8)-epoxy-17(R)-HDHA) to the trihydroxydocosahexaenoic acids 7(S), 8(R), 17(R)-triHDHA and 7(S), 16(R), 17(R)-triHDHA (AT-RvD1 and AT-RvD2 respectively) (Sun et al. 2007, Spite et al. 2009, Serhan et al. 2002). The D-resolvins are anti-inflammatory, pro-resolving, and non-phlogistic (that is, they mediate the clearance of leukocytes without eliciting an inflammatory response) (Serhan et al. 2008).
Cooper, D, Serhan, CN, Spite, M, Perretti, M, Petasis, NA, Flower, RJ, Yang, R, Summers, L, Norling, LV
Serhan, CN, Campbell, E, Colgan, SP, Oh, SF, Petasis, NA, Gotlinger, K, Yang, R, Uddin, J, Sun, YP
Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL
epoxide hydrolase activity of LTA4H:Zn2+ [cytosol]
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