RAC3 binds effectors at the plasma membrane

Stable Identifier
R-HSA-9018808
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In its active form, plasma membrane associated RAC3 binds to the following effectors:
NOX1 complex (Miyano et al. 2009)
NOX2 complex (Miyano et al. 2009)
NOX3 complex (Miyano et al. 2009)
PAK2 (Bagci et al. 2020; activation of PAK2 downstream of RAC3 was demonstrated by Mira et al. 2000, but direct binding was not tested in the study)
WAVE1 complex, through direct interaction with WASF1 (Bagci et al. 2020) and CYFIP1 (Bagci et al. 2020)
WAVE2 complex, through direct interaction with WASF2 (Bagci et al. 2020) and CYFIP1 (Bagci et al. 2020)

The following proteins are annotated as candidate RAC3 effectors because their interactions with RAC3 have not been sufficiently characterized:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
BAIAP2 (Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK1 (Mira et al. 2000: RAC3 induces PAK1 activation but direct interaction has not been tested)
PAK4 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)

Active RAC3 does not bind to the following established or putative RAC effectors:
ANKLE2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
ARMCX3 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
DOCK1 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
SHTM2 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
VAPB (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
19534724 The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases

Miyano, K, Koga, H, Minakami, R, Sumimoto, H

Biochem. J. 2009
10618392 Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

Mira, JP, Benard, V, Groffen, J, Sanders, LC, Knaus, UG

Proc Natl Acad Sci U S A 2000
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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