Reactome | RHOV binds effectors at the plasma membrane

RHOV binds effectors at the plasma membrane

Stable Identifier

R-HSA-9018794

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOV binds effectors at the plasma membrane

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In its active GTP bound form, RHOV activates the following effectors:
PAK1 (Weisz Hubsman et al. 2007; Bagci et al. 2020)
PAK2 (Aronheim et al. 1998; Bagci et al. 2020)
PAK6 (Shepelev and Korobko 2012)
The functional consequences of the interaction have only been established for RHOV and PAK1 (Weisz Hubsman et a. 2007).

The following candidate RHOV effectors were identified in the high throughput screens by Aspenström et al. 2004 and Bagci et al. 2020; the biological roles of these interactions have not been characterized:
ARHGEF7 (Bagci et al. 2020)
CCP110 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MAP3K11 (Aspenström et al. 2004)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
NCK2 (Bagci et al. 2020);
PAK4 (Aspenström et al. 2004; Bagci et al. 2020: weak interaction)
PARD6A (Aspenström et al. 2004)
PARD6B (Bagci et al. 2020: weak interaction)
PEAK1 (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WASL (Aspenström et al. 2004; Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Active RHOV does not bind the following putative effector proteins which do bind active RHOU:
HGS (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
9778532	Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton Aronheim, A, Broder, YC, Cohen, A, Fritsch, A, Belisle, B, Abo, A	Curr. Biol.	1998
14521508	Rho GTPases have diverse effects on the organization of the actin filament system Aspenstrom, P, Fransson, A, Saras, J	Biochem J	2004
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
17355222	Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp Weisz Hubsman, M, Volinsky, N, Manser, E, Yablonski, D, Aronheim, A	Biochem J	2007
22339630	Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV Shepelev, MV, Korobko, IV	Biochemistry Mosc.	2012