In its active GTP bound form, RHOV activates the following effectors:PAK1 (Weisz Hubsman et al. 2007; Bagci et al. 2020)PAK2 (Aronheim et al. 1998; Bagci et al. 2020)PAK6 (Shepelev and Korobko 2012)The functional consequences of the interaction have only been established for RHOV and PAK1 (Weisz Hubsman et a. 2007).The following candidate RHOV effectors were identified in the high throughput screens by Aspenström et al. 2004 and Bagci et al. 2020; the biological roles of these interactions have not been characterized:ARHGEF7 (Bagci et al. 2020)CCP110 (Bagci et al. 2020)CDC42 (Bagci et al. 2020)CEP97 (Bagci et al. 2020)CLTC (Bagci et al. 2020)DEPDC1B (Bagci et al. 2020)DLG5 (Bagci et al. 2020)DST (Bagci et al. 2020)EPHA2 (Bagci et al. 2020)GIT1 (Bagci et al. 2020)GIT2 (Bagci et al. 2020)IQGAP1 (Bagci et al. 2020)MAP3K11 (Aspenström et al. 2004)MAP3K21 (Bagci et al. 2020)MYH11 (Bagci et al. 2020)MYL12B (Bagci et al. 2020)MYO6 (Bagci et al. 2020)NCK1 (Bagci et al. 2020)NCK2 (Bagci et al. 2020);PAK4 (Aspenström et al. 2004; Bagci et al. 2020: weak interaction)PARD6A (Aspenström et al. 2004)PARD6B (Bagci et al. 2020: weak interaction)PEAK1 (Bagci et al. 2020)SH3RF1 (Bagci et al. 2020)SPTAN1 (Bagci et al. 2020)SPTBN1 (Bagci et al. 2020)TPM3 (Bagci et al. 2020)TPM4 (Bagci et al. 2020)TXNL1 (Bagci et al. 2020)USP9X (Bagci et al. 2020)VANGL1 (Bagci et al. 2020)WASL (Aspenström et al. 2004; Bagci et al. 2020)WDR6 (Bagci et al. 2020)ZNF512B (Bagci et al. 2020)Active RHOV does not bind the following putative effector proteins which do bind active RHOU:HGS (Bagci et al. 2020)PAK3 (Bagci et al. 2020)STAM (Bagci et al. 2020)STAM2 (Bagci et al. 2020)WWP2 (Bagci et al. 2020)
Aronheim, A, Belisle, B, Cohen, A, Abo, A, Fritsch, A, Broder, YC
Aspenstrom, P, Saras, J, Fransson, A
Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP
Aronheim, A, Weisz Hubsman, M, Yablonski, D, Volinsky, N, Manser, E
Shepelev, MV, Korobko, IV
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