RHOV binds effectors at the plasma membrane

Stable Identifier
R-HSA-9018794
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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In its active GTP bound form, RHOV binds the following effectors:
PAK2 (Aronheim et al. 1998; Bagci et al. 2020)
PAK6 (Shepelev and Korobko 2012)

The following candidate RHOV effectors were identified in the high throughput screen by Bagci et al. 2020:
ARHGAP12 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
CCP110 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
MYO9A (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
NCK2 (Bagci et al. 2020);
PAK1 (Bagci et al. 2020)
PEAK1 (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WASL (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Active RHOV does not bind the following putative effector proteins which do bind active RHOU:
HGS (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
9778532 Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

Aronheim, A, Broder, YC, Cohen, A, Fritsch, A, Belisle, B, Abo, A

Curr. Biol. 1998
22339630 Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV

Shepelev, MV, Korobko, IV

Biochemistry Mosc. 2012
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