RHOV binds effectors at the plasma membrane

Stable Identifier
R-HSA-9018794
Type
Reaction
Species
Homo sapiens
Compartment
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In its active GTP bound form, RHOV activates the following effectors:
PAK1 (Weisz Hubsman et al. 2007; Bagci et al. 2020)
PAK2 (Aronheim et al. 1998; Bagci et al. 2020)
PAK6 (Shepelev and Korobko 2012)
The functional consequences of the interaction have only been established for RHOV and PAK1 (Weisz Hubsman et a. 2007).

The following candidate RHOV effectors were identified in the high throughput screens by Aspenström et al. 2004 and Bagci et al. 2020; the biological roles of these interactions have not been characterized:
ARHGEF7 (Bagci et al. 2020)
CCP110 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MAP3K11 (Aspenström et al. 2004)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
NCK2 (Bagci et al. 2020);
PAK4 (Aspenström et al. 2004; Bagci et al. 2020: weak interaction)
PARD6A (Aspenström et al. 2004)
PARD6B (Bagci et al. 2020: weak interaction)
PEAK1 (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WASL (Aspenström et al. 2004; Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Active RHOV does not bind the following putative effector proteins which do bind active RHOU:
HGS (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
9778532 Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

Aronheim, A, Belisle, B, Cohen, A, Abo, A, Fritsch, A, Broder, YC

Curr. Biol. 1998
14521508 Rho GTPases have diverse effects on the organization of the actin filament system

Aspenstrom, P, Saras, J, Fransson, A

Biochem J 2004
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Tran, V, Gingras, AC, Elkholi, IE, Robert, A, Boulais, J, Faubert, D, Dubé, N, Hipfner, DR, Cote, JF, Lin, ZY, Bagci, H, Sriskandarajah, N, Thibault, MP

Nat. Cell Biol. 2020
17355222 Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp

Aronheim, A, Weisz Hubsman, M, Yablonski, D, Volinsky, N, Manser, E

Biochem J 2007
22339630 Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV

Shepelev, MV, Korobko, IV

Biochemistry Mosc. 2012
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