RHOBTB2 binds GTP

Stable Identifier
R-HSA-9018785
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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RHOBTB2 binds GTP
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RHOBTB2 binds to GTP, but does not switch between GDP- and GTP-bound states (Manjarrez et al. 2014). ATP-dependent protein folding chaperone activity of the HSP90:CDC37 complex and binding of RHOBTB2 to the HSP90:CDC37 complex enables RHOBTB2 to bind GTP (Manjarrez et al. 2014). There are no known RHOBTB2 GAPs - DEBDC1B was reported to bind RHOBTB2 by Bagci et al. 2020, but its RHOBTB2-directed GAP activity has not been tested.
Literature References
PubMed ID Title Journal Year
24608665 Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex

Manjarrez, JR, Sun, L, Prince, T, Matts, RL

PLoS ONE 2014
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein folding chaperone activity of HSP90:CDC37 [cytosol]

Physical Entity
HSP90:CDC37 [cytosol] (Homo sapiens)
Activity
protein folding chaperone (GO:0044183)
Orthologous Events
RHOBTB2 binds GTP (Bos taurus)
RHOBTB2 binds GTP (Canis familiaris)
RHOBTB2 binds GTP (Drosophila melanogaster)
RHOBTB2 binds GTP (Gallus gallus)
RHOBTB2 binds GTP (Mus musculus)
RHOBTB2 binds GTP (Rattus norvegicus)
RHOBTB2 binds GTP (Sus scrofa)
RHOBTB2 binds GTP (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-03-06)
Reviewed
Rivero Crespo, F  (2020-10-13)
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2017-09-05)
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