RHOBTB2 binds to GTP, but does not switch between GDP- and GTP-bound states (Manjarrez et al. 2014). ATP-dependent protein folding chaperone activity of the HSP90:CDC37 complex and binding of RHOBTB2 to the HSP90:CDC37 complex enables RHOBTB2 to bind GTP (Manjarrez et al. 2014). There are no known RHOBTB2 GAPs - DEBDC1B was reported to bind RHOBTB2 by Bagci et al. 2020, but its RHOBTB2-directed GAP activity has not been tested.
Prince, T, Matts, RL, Manjarrez, JR, Sun, L
protein folding chaperone activity of HSP90:CDC37 [cytosol]
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