Reactome | RHOU binds effectors at the plasma membrane

RHOU binds effectors at the plasma membrane

Stable Identifier

R-HSA-9018766

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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RHOU binds effectors at the plasma membrane

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In its active GTP bound form, RHOU binds the following effectors:
ARHGAP30 (Naji et al. 2011; protein with GAP activity)
ARHGAP31 (Naji et al. 2011; protein with GAP activity)
GRB2 (Zhang et al. 2011; Bagci et al. 2020: weak binding)
ITSN2 (Gubar et al. 2020)
NCK2 (Saras et al. 2004; Bagci et al. 2020)
PAK1 (Tao et al. 2001; Shutes et al. 2004; Saras et al. 2004; Bagci et al. 2020)
PAK4 (Dart et al. 2015)
PAR6 (Brady et al. 2009)
PIK3R1 (Chuang et al. 2007; Bagci et al. 2020; protein with GAP activity)
PTK2B (Ruusala and Aspenström 2008)

The following candidate RHOU effectors were identified in the high throughput screen by Bagci et al. 2020:
ARHGEF6 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020; protein with GAP activity)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
HGS (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020; protein with GAP activity)
PEAK1 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020; protein with GAP activity)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

RHOU does not bind WASL, a component of the WIP WASP complex (Bagci et al. 2020) and also does not bind:
CCP110 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
19064640	The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis Brady, DC, Alan, JK, Madigan, JP, Fanning, AS, Cox, AD	Mol Cell Biol	2009
32737221	The atypical Rho GTPase RhoU interacts with intersectin-2 to regulate endosomal recycling pathways Gubar, O, Croisé, P, Kropyvko, S, Gryaznova, T, Tóth, P, Blangy, A, Vitale, N, Rynditch, A, Gasman, S, Ory, S	J Cell Sci	2020
17504809	The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration Chuang, YY, Valster, A, Coniglio, SJ, Backer, JM, Symons, M	J Cell Sci	2007
21508312	GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration Zhang, JS, Koenig, A, Young, C, Billadeau, DD	Mol Biol Cell	2011
26598620	PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion Dart, AE, Box, GM, Court, W, Gale, ME, Brown, JP, Pinder, SE, Eccles, SA, Wells, CM	J. Cell Biol.	2015
15350535	Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects Saras, J, Wollberg, P, Aspenström, P	Exp. Cell Res.	2004
21565175	ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion Naji, L, Pacholsky, D, Aspenström, P	Biochem. Biophys. Res. Commun.	2011
15556869	Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase Shutes, A, Berzat, AC, Cox, AD, Der, CJ	Curr. Biol.	2004
11459829	Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1 Tao, W, Pennica, D, Xu, L, Kalejta, RF, Levine, AJ	Genes Dev.	2001
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020