RHOU binds effectors at the plasma membrane

Stable Identifier
Reaction [binding]
Homo sapiens
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In its active GTP bound form, RHOU binds the following effectors:
ARHGAP30 (Naji et al. 2011)
NCK2 (Saras et al. 2004; Bagci et al. 2020)
PAK1 (Tao et al. 2001; Shutes et al. 2004; Saras et al. 2004; Bagci et al. 2020)
PAK4 (Dart et al. 2015)

The following candidate RHOU effectors were identified in the high throughput screen by Bagci et al. 2020:
ARHGEF6 (Bagci et al. 2020)
ARHGEF7 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CLTC (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DLG5 (Bagci et al. 2020)
DST (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
HGS (Bagci et al. 2020)
IQGAP1 (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
NCK1 (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
PAK3 (Bagci et al. 2020)
PEAK1 (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
SPTAN1 (Bagci et al. 2020)
SPTBN1 (Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STAM (Bagci et al. 2020)
STAM2 (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
USP9X (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WDR6 (Bagci et al. 2020)
WWP2 (Bagci et al. 2020)

RHOU does not bind WASL, a component of the WIP WASP complex (Bagci et al. 2020) and also does not bind:
CCP110 (Bagci et al. 2020)
CEP97 (Bagci et al. 2020)
MAP3K21 (Bagci et al. 2020)
MYH11 (Bagci et al. 2020)
MYL12B (Bagci et al. 2020)
SH3RF1 (Bagci et al. 2020)
TPM3 (Bagci et al. 2020)
TPM4 (Bagci et al. 2020)
ZNF512B (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
15350535 Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects

Saras, J, Wollberg, P, Aspenström, P

Exp. Cell Res. 2004
26598620 PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

Dart, AE, Box, GM, Court, W, Gale, ME, Brown, JP, Pinder, SE, Eccles, SA, Wells, CM

J. Cell Biol. 2015
21565175 ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion

Naji, L, Pacholsky, D, Aspenström, P

Biochem. Biophys. Res. Commun. 2011
15556869 Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

Shutes, A, Berzat, AC, Cox, AD, Der, CJ

Curr. Biol. 2004
11459829 Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

Tao, W, Pennica, D, Xu, L, Kalejta, RF, Levine, AJ

Genes Dev. 2001
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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