Reactome | Biosynthesis of EPA-derived SPMs

Biosynthesis of EPA-derived SPMs

Stable Identifier

R-HSA-9018679

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of E-series resolvins (RvEs), one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017). The biosynthesis of RvEs occurs mainly during the process of inflammation when endothelial cells interact with leukocytes. EPA, circulating in plasma or released/mobilised from damaged cellular membranes on injury or infection, moves with edema into the tissue sites of acute inflammation where it is converted to exudate RvEs to interact with local immune cells (Kasuga et al. 2008). The initial transformation of EPA by aspirin-acetylated cyclooxygenase 2- and/or cytochrome P450-mediated catalysis can produce stereospecific resolvins (18(R)- or 18(S)-RvEs). Combinations of oxidation, reduction and hydrolysis reactions determine the type of resolvin formed (RvE1, RvE2 or RvE3) (Serhan et al. 2000, 2002, Serhan & Petasis 2011, Maehre et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26393581	ω-3 Fatty Acids and Cardiovascular Diseases: Effects, Mechanisms and Dietary Relevance Maehre, HK, Elvevoll, EO, Jensen, IJ, Eilertsen, KE	Int J Mol Sci	2015
11034610	Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing Chiang, N, Colgan, SP, Serhan, CN, Brannon, J, Gronert, K, Clish, CB	J. Exp. Med.	2000
12391014	Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals Gronert, K, Serhan, CN, Devchand, PR, Colgan, SP, Hong, S, Mirick, G, Moussignac, RL	J. Exp. Med.	2002
21766791	Resolvins and protectins in inflammation resolution Serhan, CN, Petasis, NA	Chem. Rev.	2011