Reactome | Biosynthesis of E-series 18(R)-resolvins

Biosynthesis of E-series 18(R)-resolvins

Stable Identifier

R-HSA-9023661

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Biosynthesis of E-series 18(R)-resolvins

Click the image above or here to open this pathway in the Pathway Browser

Eicosapentaenoic acid (EPA), a major ω-3 polyunsaturated fatty acid (PUFA) found in fish oil is the source of E-series resolvins, one of the specialized proresolving mediators (SPMs) that show potent anti-inflammatory and pro-resolving actions (Molfino et al. 2017, Calder 2017). The initial transformation of EPA can be mediated by either cytochrome P450s or aspirin-acetylated cyclooxygenase-2, resulting in 18(R)- and 18(S)-stereospecific E-resolvins. Combinations of oxidation, reduction and hydrolysis reactions determine the type of E-resolvin formed (RvE1, RvE2 or RvE3) (Serhan & Petasis 2011). Aspirin acetylation of cyclooxygenase isoforms results in changed activities. Acetylation of cyclooxygenase-1 results in its inhibition and thereby halting production of inflammatory mediators. However, acetylation of cyclooxygenase-2 transforms its enzyme activity from a cyclooxygenase to a lipoxygenase, thereby blocking prostaglandin biosynthesis and, additionally, initiating the production of SPMs (Arita et al. 2005, Kyriakopoulos et al. 2017). The biosynthesis of 18(R) E-resolvins is described here.

Literature References

PubMed ID	Title	Journal	Year
16112645	The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids Serhan, CN, Arita, M, Clish, CB	Biochem. Biophys. Res. Commun.	2005
28900017	Omega-3 fatty acids and inflammatory processes: from molecules to man Calder, PC	Biochem. Soc. Trans.	2017
28573063	Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs Nagl, M, Baliou, S, Zoumpourlis, V, Kyriakopoulos, AM	Int J Inflam	2017
21766791	Resolvins and protectins in inflammation resolution Serhan, CN, Petasis, NA	Chem. Rev.	2011