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EGF:p-6Y-EGFR dimer [plasma membrane]
Stable Identifier
R-HSA-179882
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EGF:Phospho-EGFR (Y1016, Y1092, Y1110, Y1172, Y1197) dimer, EGF:Phospho-EGFR (Y992, Y1068, Y1086, Y1148, Y1173) dimer
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
EGFR phosphorylates NOTCH3 (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
NOTCH3 binds activated EGFR (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)
EGF:p-6Y-EGFR dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
EGF:Phospho-EGFR [plasma membrane]
(Homo sapiens)
Participates
as an output of
EGFR phosphorylates NOTCH3 (Homo sapiens)
as a component of
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
as an input of
NOTCH3 binds activated EGFR (Homo sapiens)
PTPN12 dephosphorylates EGFR at Y1172 (Y1148) (Homo sapiens)
as a candidate of
Activated SRC,LCK,EGFR,INSR [plasma membrane] (Homo sapiens)
Inferred To
EGF:p-6Y-EGFR dimer [plasma membrane]
(Caenorhabditis elegans)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Canis familiaris)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Drosophila melanogaster)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Gallus gallus)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Mus musculus)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Rattus norvegicus)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Sus scrofa)
EGF:p-6Y-EGFR dimer [plasma membrane]
(Xenopus tropicalis)
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