EGFR phosphorylates NOTCH3

Stable Identifier
R-HSA-9018572
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) on an unknown tyrosine residue. EGFR signaling inhibits NICD3-mediated transcription. It is not known whether EGFR-mediated phosphorylation of NICD3 affects NICD3 nuclear translocation or the formation of the NOTCH3 coactivator complex. Erlotinib treatment, which inhibits EGFR activation, results in increased NOTCH3 signaling and induction of stem-like phenotype in treated cells (Arasada et al. 2014).

Literature References
PubMed ID Title Journal Year
25125655 EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling

Arasada, RR, Amann, JM, Rahman, MA, Huppert, SS, Carbone, DP

Cancer Res. 2014
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Event Information
Catalyst Activity

protein tyrosine kinase activity of EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]

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