EGFR phosphorylates NOTCH3

Stable Identifier
R-HSA-9018572
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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EGFR phosphorylates NOTCH3
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EGFR phosphorylates intracellular domain of NOTCH3 (NICD3) on an unknown tyrosine residue. EGFR signaling inhibits NICD3-mediated transcription. It is not known whether EGFR-mediated phosphorylation of NICD3 affects NICD3 nuclear translocation or the formation of the NOTCH3 coactivator complex. Erlotinib treatment, which inhibits EGFR activation, results in increased NOTCH3 signaling and induction of stem-like phenotype in treated cells (Arasada et al. 2014).
Literature References
PubMed ID Title Journal Year
25125655 EGFR blockade enriches for lung cancer stem-like cells through Notch3-dependent signaling

Huppert, SS, Carbone, DP, Arasada, RR, Rahman, MA, Amann, JM

Cancer Res. 2014
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of Notch signaling pathway (0045746)
Catalyst Activity

protein tyrosine kinase activity of EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane]

Physical Entity
EGF:p-6Y-EGFR dimer:NICD3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
EGFR phosphorylates NOTCH3 (Gallus gallus)
EGFR phosphorylates NOTCH3 (Mus musculus)
EGFR phosphorylates NOTCH3 (Rattus norvegicus)
EGFR phosphorylates NOTCH3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-09-01)
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