Reactome | RHOJ GEFs activate RHOJ

RHOJ GEFs activate RHOJ

Stable Identifier

R-HSA-9017491

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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DOCK8 guanine nucleotide exchange factors (GEFs) was shown to bind RHOJ and catalyze GDP to GTP exchange on RHOJ, resulting in formation of the active RHOJ:GTP complex (Ruusala and Aspenstrom 2004).
PREX1 (Jaiswal et al. 2013) and TRIO (Jaiswal et al. 2013) exhibited very low RHOJ-directed GEF activity, being hundred times and thousand times, respectively, less active on RHOJ than on CDC42 and RHOG. They are annotated as candidate RHOJ GEFs.

The following GEFs do not act on RHOJ:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF15 (Kusuhara et al. 2012)
ARHGEF28 (also known as p190RhoGEF, KIAA1998 or RGNEF) (Jaiswal et al. 2013)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9 (Nishikimi et al. 2005)
DOCK11 (Nishikimi et al. 2005)
ITSN1 (Jaiswal et al. 2013)
MCF2 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)
VAV2 (Jaiswal et al. 2013)

Literature References

PubMed ID	Title	Journal	Year
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Ahmadian, MR, Jaiswal, M, Dvorsky, R	J. Biol. Chem.	2013
23029280	Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells Shimizu, Y, Nishida, K, Nishikawa, S, Jakt, LM, Hirashima, M, Fukushima, Y, Hata, M, Uemura, A, Mochizuki, N, Okada, M, Negi, A, Fukuhara, S, Kusuhara, S	PLoS ONE	2012
15304341	Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology Ruusala, A, Aspenström, P	FEBS Lett.	2004
15710388	Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes Meller, N, Schwartz, MA, Maruyama, M, Nishikimi, A, Uekawa, N, Isobe, K	FEBS Lett	2005