RHOJ GEFs activate RHOJ

Stable Identifier
Reaction [transition]
Homo sapiens
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DOCK8 guanine nucleotide exchange factors (GEFs) was shown to bind RHOJ and catalyze GDP to GTP exchange on RHOJ, resulting in formation of the active RHOJ:GTP complex (Ruusala and Aspenstrom 2004).
PREX1 (Jaiswal et al. 2013) and TRIO (Jaiswal et al. 2013) exhibited very low RHOJ-directed GEF activity, being hundred times and thousand times, respectively, less active on RHOJ than on CDC42 and RHOG. They are annotated as candidate RHOJ GEFs.

The following GEFs do not act on RHOJ:
ARHGEF1 (Jaiswal et al. 2013)
ARHGEF11 (Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2013)
ARHGEF15 (Kusuhara et al. 2012)
ARHGEF28 (also known as p190RhoGEF, KIAA1998 or RGNEF) (Jaiswal et al. 2013)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
DOCK9 (Nishikimi et al. 2005)
DOCK11 (Nishikimi et al. 2005)
ITSN1 (Jaiswal et al. 2013)
MCF2 (Jaiswal et al. 2013)
MCF2L (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)
VAV2 (Jaiswal et al. 2013)

Literature References
PubMed ID Title Journal Year
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Ahmadian, MR, Jaiswal, M, Dvorsky, R

J. Biol. Chem. 2013
23029280 Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells

Shimizu, Y, Nishida, K, Nishikawa, S, Jakt, LM, Hirashima, M, Fukushima, Y, Hata, M, Uemura, A, Mochizuki, N, Okada, M, Negi, A, Fukuhara, S, Kusuhara, S

PLoS ONE 2012
15304341 Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

Ruusala, A, Aspenström, P

FEBS Lett. 2004
15710388 Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes

Meller, N, Schwartz, MA, Maruyama, M, Nishikimi, A, Uekawa, N, Isobe, K

FEBS Lett 2005
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOJ GEFs [cytosol]

Orthologous Events
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