IK1 binds the PTCRA gene promoter

Stable Identifier
R-HSA-9017120
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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IK1 binds the PTCRA gene promoter
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IK1, the splicing isoform 1 of the transcription factor Ikaros (IKZF1), binds to the promoter of the PTCRA gene, encoding pre-TCR-alpha. IK1-bindining sites overlap with RBPJ-binding sites. Therefore, IK1 competes with NOTCH3 coactivator complexes for binding to the PTCRA promoter (Bellavia et al. 2007). It is unknown which IK1 heterodimerization partners are involved in binding to the PTCRA promoter.
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Event Information
Go Biological Process
negative regulation of transcription initiation from RNA polymerase II promoter (0060633)
Inferred From
Ik1 binds the Ptcra gene promoter (Mus musculus)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-08-16)
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