Reactome | IK1 [nucleoplasm]

IK1 [nucleoplasm]

Stable Identifier

R-HSA-9017118

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

IKZF1-1, DNA-binding protein Ikaros isoform 1, Ikaros-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13422-1 IKZF1

Gene Names

IKZF1, IK1, IKAROS, LYF1, ZNFN1A1

Other Identifiers

10320

11742022_s_at

11749209_s_at

11758671_s_at

1565817_PM_at

1565817_at

1565818_PM_s_at

1565818_s_at

17046041

205038_PM_at

205039_PM_s_at

205039_s_at

216901_PM_s_at

216901_s_at

227344_PM_at

227344_at

227346_PM_at

227346_at

3001482

3001483

3001492

3001496

3001508

3001509

3001515

3001518

3001520

3001521

3001527

3001528

3001529

3001530

3001531

3001532

3001533

3001534

3001535

3001536

3001537

3001538

40007_at

64704_at

81142_at

8132819

834_at

85771_at

89942_at

A_23_P135646

A_24_P190631

A_33_P3842556

GE59138

GO:0000978

GO:0002376

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005737

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0007049

GO:0007498

GO:0019904

GO:0030098

GO:0030154

GO:0030218

GO:0032991

GO:0042802

GO:0043226

GO:0045892

GO:0046872

GO:0048856

GO:0140110

HMNXSV003037029

HMNXSV003050972

Hs.121587.0.S1_3p_at

Hs.121587.0.S2_3p_at

Hs.54452.1.S1_3p_a_at

Hs2.409775.1.S1_3p_s_at

ILMN_1676575

PH_hs_0025454

U40462_at

g5174500_3p_a_at

Participates

as a component of

IK1:PTCRA gene [nucleoplasm] (Homo sapiens)

as an input of

IK1 binds the PTCRA gene promoter (Homo sapiens)

Cross References

RefSeq

NP_001278770.1, NP_001278773.1, NP_001278766.1, NP_001207697.1, NP_001278768.1, NP_001278771.1, XP_011513377.1, NP_001207694.1, XP_011513370.1, XP_016867157.1, NP_001207699.1, XP_011513378.1, NP_001207700.1, NP_001278767.1, NP_001278772.1, NP_001207696.1, NP_006051.1, XP_011513371.1, NP_001278769.1

OpenTargets

ENSG00000185811

HPA

ENSG00000185811-IKZF1

GeneCards

Q13422

Ensembl

ENSP00000396554, ENST00000698575, ENSP00000513806, ENSP00000413025, ENSP00000331614, ENST00000331340, ENSG00000185811, ENST00000438033, ENSP00000352123, ENST00000439701, ENST00000359197

PRO

Q13422

Pharos - Targets

Q13422

Orphanet

21608

PDB

8D7Z, 8D80, 6H0F

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.742	5
UniProt:O43602 DCX	1	DCX [cytosol] (R-HSA-430060)	0.666	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.666	4
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.666	5
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.556	3
UniProt:Q13526 PIN1	2	PIN1 [cytosol] (R-HSA-9626823) PIN1 [nucleoplasm] (R-HSA-936016)	0.556	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.556	3
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q92630 DYRK2	3	PolyUb-DYRK2 [nucleoplasm] (R-HSA-6798383) DYRK2 [nucleoplasm] (R-HSA-3215037) p-T106,S442-DYRK2 [nucleoplasm] (R-HSA-6798368)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	5
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3