RAC2 binds effectors at the plasma membrane

Stable Identifier
R-HSA-9014294
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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In its GTP bound active form, plasma membrane associated RAC2 binds to the following effectors:
IQGAP1 (Meng et al. 2007)
KIAA0355 (Bagci et al. 2020: interaction tested in detail)
PAK1 (Knaus et al. 1998; Hoppe and Swanson 2004; Carstanjen et al. 2005)
PAK4 (Zhang et al. 2019; Bagci et al. 2020)
PI3K alpha (Bokoch et al. 1996)
PLD2 (Peng et al. 2011)

The following candidate RAC2 effectors have so far only been reported in the high throughput screen by Bagci et al. 2020:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WAVE2 regulatory complex (interacts with subunits CYFIP1 and WASF2) (Bagci et al. 2020)

RAC2 does not bind the following RHO GTPase effectors:
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
BAIAP2 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
DOCK1 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SHMT2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
WAVE1 complex subunit WASF1 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
15169870 Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis

Hoppe, AD, Swanson, JA

Mol Biol Cell 2004
11145705 Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways

Kim, C, Dinauer, MC

J. Immunol. 2001
21378159 Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2

Peng, HJ, Henkels, KM, Mahankali, M, Dinauer, MC, Gomez-Cambronero, J

J. Biol. Chem. 2011
31389670 Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4

Zhang, X, Fang, J, Chen, S, Wang, W, Meng, S, Liu, B

Cancer Med 2019
1660188 Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2

Knaus, UG, Heyworth, PG, Evans, T, Curnutte, JT, Bokoch, GM

Science 1991
17269730 Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion

Meng, X, Krokhin, O, Cheng, K, Ens, W, Wilkins, JA

J. Proteome Res. 2007
15814684 Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways

Carstanjen, D, Yamauchi, A, Koornneef, A, Zang, H, Filippi, MD, Harris, C, Towe, J, Atkinson, S, Zheng, Y, Dinauer, MC, Williams, DA

J. Immunol. 2005
8645157 Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE

Biochem J 1996
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
9705280 Structural requirements for PAK activation by Rac GTPases

Knaus, UG, Wang, Y, Reilly, AM, Warnock, D, Jackson, JH

J Biol Chem 1998
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