Reactome | RAC2 binds effectors at the plasma membrane

RAC2 binds effectors at the plasma membrane

Stable Identifier

R-HSA-9014294

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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RAC2 binds effectors at the plasma membrane

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In its GTP bound active form, plasma membrane associated RAC2 binds to the following effectors:
IQGAP1 (Meng et al. 2007)
KIAA0355 (Bagci et al. 2020: interaction tested in detail)
PAK1 (Knaus et al. 1998; Hoppe and Swanson 2004; Carstanjen et al. 2005)
PAK4 (Zhang et al. 2019; Bagci et al. 2020)
PI3K alpha (Bokoch et al. 1996)
PLD2 (Peng et al. 2011)

The following candidate RAC2 effectors have so far only been reported in the high throughput screen by Bagci et al. 2020:
ABI1 (Bagci et al. 2020)
ABI2 (Bagci et al. 2020)
BAIAP2L1 (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CDC42 (Bagci et al. 2020)
CDC42EP1 (Bagci et al. 2020)
CDC42EP4 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
DSG2 (Bagci et al. 2020)
EPHA2 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
GIT1 (Bagci et al. 2020)
GIT2 (Bagci et al. 2020)
ITGB1 (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MPP7 (Bagci et al. 2020)
NCKAP1 (Bagci et al. 2020)
NHS (Bagci et al. 2020)
PAK2 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
SLITRK5 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
SWAP70 (Bagci et al. 2020)
TAOK3 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
WAVE2 regulatory complex (interacts with subunits CYFIP1 and WASF2) (Bagci et al. 2020)

RAC2 does not bind the following RHO GTPase effectors:
ABL2 (Bagci et al. 2020)
AMIGO2 (Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARFGAP3 (Bagci et al. 2020)
BAIAP2 (Bagci et al. 2020)
BRK1 (Bagci et al. 2020)
DOCK1 (Bagci et al. 2020)
DOCK5 (Bagci et al. 2020)
ELMO2 (Bagci et al. 2020)
FERMT2 (Bagci et al. 2020)
HSPE1 (Bagci et al. 2020)
IL32 (Bagci et al. 2020)
JAG1 (Bagci et al. 2020)
LETM1 (Bagci et al. 2020)
NDUFA5 (Bagci et al. 2020)
NDUFS3 (Bagci et al. 2020)
PLEKHG3 (Bagci et al. 2020)
PLEKHG4 (Bagci et al. 2020)
RAPGEF1 (Bagci et al. 2020)
SHMT2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLITRK3 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
WAVE1 complex subunit WASF1 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)

Literature References

PubMed ID	Title	Journal	Year
15169870	Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis Hoppe, AD, Swanson, JA	Mol Biol Cell	2004
11145705	Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways Kim, C, Dinauer, MC	J. Immunol.	2001
21378159	Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2 Peng, HJ, Henkels, KM, Mahankali, M, Dinauer, MC, Gomez-Cambronero, J	J. Biol. Chem.	2011
31389670	Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4 Zhang, X, Fang, J, Chen, S, Wang, W, Meng, S, Liu, B	Cancer Med	2019
1660188	Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2 Knaus, UG, Heyworth, PG, Evans, T, Curnutte, JT, Bokoch, GM	Science	1991
17269730	Characterization of IQGAP1-containing complexes in NK-like cells: evidence for Rac 2 and RACK1 association during homotypic adhesion Meng, X, Krokhin, O, Cheng, K, Ens, W, Wilkins, JA	J. Proteome Res.	2007
15814684	Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways Carstanjen, D, Yamauchi, A, Koornneef, A, Zang, H, Filippi, MD, Harris, C, Towe, J, Atkinson, S, Zheng, Y, Dinauer, MC, Williams, DA	J. Immunol.	2005
8645157	Rac GTPase interacts specifically with phosphatidylinositol 3-kinase Bokoch, GM, Vlahos, CJ, Wang, Y, Knaus, UG, Traynor-Kaplan, AE	Biochem J	1996
31871319	Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF	Nat. Cell Biol.	2020
9705280	Structural requirements for PAK activation by Rac GTPases Knaus, UG, Wang, Y, Reilly, AM, Warnock, D, Jackson, JH	J Biol Chem	1998