GDIs block activation of RHOA

Stable Identifier
R-HSA-9012835
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The following GDP dissociation inhibitors (GDIs) bind to RHOA and inhibit its activation:
ARHGDIA (Boulter et al. 2010; Man et al. 2010; Gupta et al. 2013)
ARHGDIB (Watanabe et al. 2012)

ARHGDIG was shown to bind to RHOA by Adra et al. 1997, but no binding and no RHOA inhibition was detected by Zalcman et al. 1996. ARHGDIG is annotated as a candidate RHOA GDI.

Literature References
PubMed ID Title Journal Year
20400958 Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1

Boulter, E, Garcia-Mata, R, Guilluy, C, Dubash, A, Rossi, G, Brennwald, PJ, Burridge, K

Nat. Cell Biol. 2010
9113980 RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

Adra, CN, Manor, D, Ko, JL, Zhu, S, Horiuchi, T, Van Aelst, L, Cerione, RA, Lim, B

Proc Natl Acad Sci U S A 1997
20628200 Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells

Man, JH, Liang, B, Gu, YX, Zhou, T, Li, AL, Li, T, Jin, BF, Bai, B, Zhang, HY, Zhang, WN, Li, WH, Gong, WL, Li, HY, Zhang, XM

J. Clin. Invest. 2010
21936715 The hematopoietic cell-specific Rho GTPase inhibitor ARHGDIB/D4GDI limits HIV type 1 replication

Watanabe, T, Urano, E, Miyauchi, K, Ichikawa, R, Hamatake, M, Misawa, N, Sato, K, Ebina, H, Koyanagi, Y, Komano, J

AIDS Res. Hum. Retroviruses 2012
23434736 ARHGDIA: a novel gene implicated in nephrotic syndrome

Gupta, IR, Baldwin, C, Auguste, D, Ha, KC, El Andalousi, J, Fahiminiya, S, Bitzan, M, Bernard, C, Akbari, MR, Narod, SA, Rosenblatt, DS, Majewski, J, Takano, T

J. Med. Genet. 2013
8939998 RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

Zalcman, G, Closson, V, Camonis, J, Honoré, N, Rousseau-Merck, MF, Tavitian, A, Olofsson, B

J. Biol. Chem. 1996
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