RHOA GTPase cycle

Stable Identifier
R-HSA-8980692
Type
Pathway
Species
Homo sapiens
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This pathway catalogues RHOA guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOA effectors. RHOA is one of the three best characterized RHO GTPases, the other two being RAC1 and CDC42, and is the founding member of the RHO GTPase family (Zhou and Zheng 2013). RHOA regulates the cytoskeleton and cell contractility (Lessey et al. 2012), thus playing a role in a number of cellular functions, such as adhesion, migration, survival, division, vesicle trafficking and gene expression (Zhou and Zheng 2013). RHOA-regulated processes are involved in mechanotransduction (Lessey et al. 2012; Marjoram et al. 2014), neuronal development (Zhou and Zheng 2013; Fujita and Yamashita 2014; Hu and Selzer 2017), immune system development (Zhou and Zheng 2013; Ricker et al. 2016; Bros et al. 2019), and cardiovascular regulation (Zhou and Zheng 2013; Cai et al. 2016; Shimokawa et al. 2016). RHOA mutations are frequently found in cancer (Kataoka and Ogawa 2016). Toxins of numerous pathogens target RHOA to hijack the host cytoskeleton (Jamilloux et al. 2018).

Literature References
PubMed ID Title Journal Year
24467208 Regulation of RhoA activity by adhesion molecules and mechanotransduction

Marjoram, RJ, Lessey, EC, Burridge, K

Curr. Mol. Med. 2014
31319592 RhoA as a Key Regulator of Innate and Adaptive Immunity

Bros, M, Haas, K, Moll, L, Grabbe, S

Cells 2019
32203420 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller, PM, Rademacher, J, Bagshaw, RD, Wortmann, C, Barth, C, van Unen, J, Alp, KM, Giudice, G, Eccles, RL, Heinrich, LE, Pascual-Vargas, P, Sanchez-Castro, M, Brandenburg, L, Mbamalu, G, Tucholska, M, Spatt, L, Czajkowski, MT, Welke, RW, Zhang, S, Nguyen, V, Rrustemi, T, Trnka, P, Freitag, K, Larsen, B, Popp, O, Mertins, P, Gingras, AC, Roth, FP, Colwill, K, Bakal, C, Pertz, O, Pawson, T, Petsalaki, E, Rocks, O

Nat Cell Biol 2020
27693615 Variegated RHOA mutations in human cancers

Kataoka, K, Ogawa, S

Exp. Hematol. 2016
27785353 The RhoA-ROCK pathway in the regulation of T and B cell responses

Ricker, E, Chowdhury, L, Yi, W, Pernis, AB

F1000Res 2016
24202176 Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting

Zhou, X, Zheng, Y

J. Biol. Chem. 2013
25374504 Axon growth inhibition by RhoA/ROCK in the central nervous system

Fujita, Y, Yamashita, T

Front Neurosci 2014
26556565 Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system

Cai, A, Li, L, Zhou, Y

J. Hypertens. 2016
29718184 The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes

Jamilloux, Y, Magnotti, F, Belot, A, Henry, T

Pathog Dis 2018
26838319 RhoA/Rho-Kinase in the Cardiovascular System

Shimokawa, H, Sunamura, S, Satoh, K

Circ. Res. 2016
28553321 RhoA as a target to promote neuronal survival and axon regeneration

Hu, J, Selzer, ME

Neural Regen Res 2017
22931484 From mechanical force to RhoA activation

Lessey, EC, Guilluy, C, Burridge, K

Biochemistry 2012
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