Reactome | RHOA GTPase cycle

RHOA GTPase cycle

Stable Identifier

R-HSA-8980692

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOA guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOA effectors. RHOA is one of the three best characterized RHO GTPases, the other two being RAC1 and CDC42, and is the founding member of the RHO GTPase family (Zhou and Zheng 2013). RHOA regulates the cytoskeleton and cell contractility (Lessey et al. 2012), thus playing a role in a number of cellular functions, such as adhesion, migration, survival, division, vesicle trafficking and gene expression (Zhou and Zheng 2013). RHOA-regulated processes are involved in mechanotransduction (Lessey et al. 2012; Marjoram et al. 2014), neuronal development (Zhou and Zheng 2013; Fujita and Yamashita 2014; Hu and Selzer 2017), immune system development (Zhou and Zheng 2013; Ricker et al. 2016; Bros et al. 2019), and cardiovascular regulation (Zhou and Zheng 2013; Cai et al. 2016; Shimokawa et al. 2016). RHOA mutations are frequently found in cancer (Kataoka and Ogawa 2016). Toxins of numerous pathogens target RHOA to hijack the host cytoskeleton (Jamilloux et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
31319592	RhoA as a Key Regulator of Innate and Adaptive Immunity Moll, L, Grabbe, S, Bros, M, Haas, K	Cells	2019
24467208	Regulation of RhoA activity by adhesion molecules and mechanotransduction Lessey, EC, Burridge, K, Marjoram, RJ	Curr. Mol. Med.	2014
32203420	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions Pawson, T, Freitag, K, Zhang, S, Bakal, C, Popp, O, Petsalaki, E, Giudice, G, Mertins, P, Bagshaw, RD, Larsen, B, Rrustemi, T, Brandenburg, L, Nguyen, V, Roth, FP, Sanchez-Castro, M, Barth, C, Eccles, RL, Czajkowski, MT, Rademacher, J, Colwill, K, Pascual-Vargas, P, Wortmann, C, Pertz, O, Tucholska, M, Alp, KM, Rocks, O, Trnka, P, Mbamalu, G, van Unen, J, Spatt, L, Müller, PM, Heinrich, LE, Welke, RW, Gingras, AC	Nat Cell Biol	2020
27693615	Variegated RHOA mutations in human cancers Ogawa, S, Kataoka, K	Exp. Hematol.	2016
27785353	The RhoA-ROCK pathway in the regulation of T and B cell responses Pernis, AB, Yi, W, Ricker, E, Chowdhury, L	F1000Res	2016
24202176	Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting Zhou, X, Zheng, Y	J. Biol. Chem.	2013
25374504	Axon growth inhibition by RhoA/ROCK in the central nervous system Yamashita, T, Fujita, Y	Front Neurosci	2014
26556565	Pathophysiological effects of RhoA and Rho-associated kinase on cardiovascular system Cai, A, Zhou, Y, Li, L	J. Hypertens.	2016
29718184	The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes Jamilloux, Y, Henry, T, Belot, A, Magnotti, F	Pathog Dis	2018
26838319	RhoA/Rho-Kinase in the Cardiovascular System Satoh, K, Sunamura, S, Shimokawa, H	Circ. Res.	2016
28553321	RhoA as a target to promote neuronal survival and axon regeneration Hu, J, Selzer, ME	Neural Regen Res	2017
22931484	From mechanical force to RhoA activation Burridge, K, Lessey, EC, Guilluy, C	Biochemistry	2012