Reactome | IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37

IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37

Stable Identifier

R-HSA-9012556

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IL-37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL-37, CASP1 active tetramer complex cleaves IL-37

ReviewStatus

5/5

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IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37

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Interleukins (IL) are immunomodulatory proteins that elicit a wide array of responses in cells and tissues. Interleukin 37 (IL-37, IL-1 F7) is a member of the IL-1 family. There are five isoforms of IL-37 (a-e) of which transcript IL-37b is known to be functional (Sharma et al. 2008). This isoform is represented in UniProt as the canonical form of IL-37 and in Reactome as the full length, unprocessed form of IL-37. Like several other IL-1 family members, IL-37 is synthesized as a precursor that requires processing (primarily by caspase 1) to attain full receptor agonist or antagonist function. The putative caspase 1 cleavage site is at aspartic acid 20 (Kumar et al. 2002). However, other truncation sites in IL-37 have been suggested (Pan et al. 2001). Caspase 1 may not be the only enzyme responsible for IL-37 processing (Sharma et al. 2008). This is a black box event because the cleavage sites and the enzymes responsible for the processing of IL-37 are uncertain.

Literature References

PubMed ID	Title	Journal	Year
18390730	The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines Sharma, S, Kulk, N, Nold, MF, Gräf, R, Kim, SH, Reinhardt, D, Dinarello, CA, Bufler, P	J. Immunol.	2008
11145836	IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp Pan, G, Risser, P, Mao, W, Baldwin, DT, Zhong, AW, Filvaroff, E, Yansura, D, Lewis, L, Eigenbrot, C, Henzel, WJ, Vandlen, R	Cytokine	2001
24481253	Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses Bulau, AM, Nold, MF, Li, S, Nold-Petry, CA, Fink, M, Mansell, A, Schwerd, T, Hong, J, Rubartelli, A, Dinarello, CA, Bufler, P	Proc. Natl. Acad. Sci. U.S.A.	2014
12096920	Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production Kumar, S, Hanning, CR, Brigham-Burke, MR, Rieman, DJ, Lehr, R, Khandekar, S, Kirkpatrick, RB, Scott, GF, Lee, JC, Lynch, FJ, Gao, W, Gambotto, A, Lotze, MT	Cytokine	2002