Reactome | ME2 [mitochondrial matrix]

ME2 [mitochondrial matrix]

Stable Identifier

R-HSA-9012080

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Citric acid cycle (TCA cycle) (Homo sapiens)
      - ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR (Homo sapiens)
        
        ME2:Mg2+ tetramer [mitochondrial matrix] (Homo sapiens)
        
        ME2:Mg2+ dimer [mitochondrial matrix] (Homo sapiens)
        
        ME2:Mg2+ [mitochondrial matrix] (Homo sapiens)
        
        ME2 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23368 ME2

Gene Names

ME2

Chain

transit peptide:1-18, chain:19-584

Reference Genes

BioGPS Gene:4200 ME2

COSMIC (genes):ME2 ME2

CTD Gene:4200 ME2

dbSNP Gene:4200 ME2

ENSEMBL:ENSG00000082212 ME2

HGNC:6984 ME2

KEGG Gene (Homo sapiens):4200 ME2

Monarch:4200 ME2

NCBI Gene:4200 ME2

OMIM:154270 ME2

UCSC:P23368 ME2

Reference Transcript

Other Identifiers

0006770079

11739452_a_at

11739453_a_at

16852331

209397_at

210153_s_at

210154_at

36599_at

3788226

3788231

3788234

3788236

3788237

3788239

3788241

3788242

3788243

3788244

3788245

3788248

3788249

3788250

3788256

3788258

3788259

3788260

3788261

3788262

3788263

3788265

3788267

3788269

4200

8021208

A_23_P321261

A_24_P348090

GE57978

GO:0003674

GO:0003824

GO:0004470

GO:0004471

GO:0004473

GO:0005575

GO:0005622

GO:0005737

GO:0005739

GO:0005759

GO:0006090

GO:0006091

GO:0006099

GO:0006108

GO:0008150

GO:0008152

GO:0008948

GO:0009055

GO:0016491

GO:0016829

GO:0022900

GO:0043167

GO:0043226

GO:0043231

GO:0044281

GO:0046872

GO:0051287

GO:0055114

GO:1902031

ILMN_1675186

ILMN_2048636

M55905_at

PH_hs_0004315

TC18000180.hg

g12652790_3p_at

g187299_3p_a_at

Participant Of

hasComponent

ME2:Mg2+ [mitochondrial matrix]

Inferred To

noc3l [mitochondrial matrix] (Xenopus tropicalis)

Me2 [mitochondrial matrix] (Mus musculus)

Me2 [mitochondrial matrix] (Rattus norvegicus)

ME2 [mitochondrial matrix] (Bos taurus)

ME2 [mitochondrial matrix] (Canis familiaris)

ME2 [mitochondrial matrix] (Sus scrofa)

me2 [mitochondrial matrix] (Danio rerio)

malA [mitochondrial matrix] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002387.1, NP_001161807.1

OpenTargets

ENSG00000082212

HPA

ENSG00000082212-ME2

GeneCards

P23368

Ensembl

ENST00000321341, ENSG00000082212, ENSP00000321070, ENSP00000372384, ENST00000382927

PRO

P23368

HMDB Protein

HMDBP00862

PDB

1QR6, 1EFK, 1DO8, 1EFL, 1PJ4, 1PJ2, 1PJ3, 1GZ3, 1GZ4, 1PJL

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