Reactome | ME2 [mitochondrial matrix]

ME2 [mitochondrial matrix]

Stable Identifier

R-HSA-9012080

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism (Homo sapiens)
    - ME2 tetramer decarboxylates MAL to PYR (Homo sapiens)
      - ME2:Mg2+ tetramer [mitochondrial matrix] (Homo sapiens)
        
        ME2:Mg2+ dimer [mitochondrial matrix] (Homo sapiens)
        
        ME2:Mg2+ [mitochondrial matrix] (Homo sapiens)
        
        ME2 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23368 ME2

Gene Names

ME2

Chain

transit peptide:1-18, chain:19-584

Reference Genes

BioGPS Gene:4200 ME2

COSMIC (genes):ME2 ME2

CTD Gene:4200 ME2

dbSNP Gene:4200 ME2

ENSEMBL:ENSG00000082212 ME2

HGNC:6984 ME2

KEGG:hsa:4200 ME2

Monarch:4200 ME2

NCBI Gene:4200 ME2

OMIM:154270 ME2

UCSC:P23368 ME2

Reference Transcript

Other Identifiers

11739452_a_at

11739453_a_at

1562612_PM_at

1562612_at

16852331

209397_PM_at

209397_at

210153_PM_s_at

210153_s_at

210154_PM_at

210154_at

36599_at

3788226

3788227

3788230

3788231

3788234

3788236

3788237

3788238

3788239

3788240

3788241

3788242

3788243

3788244

3788245

3788248

3788249

3788250

3788251

3788252

3788253

3788254

3788255

3788256

3788257

3788258

3788259

3788260

3788261

3788262

3788263

3788265

3788267

3788269

4200

8021208

A_14_P110781

A_23_P321261

A_24_P348090

GE57978

GE623629

GO:0003824

GO:0004470

GO:0004471

GO:0004473

GO:0005739

GO:0005759

GO:0006108

GO:0008948

GO:0009055

GO:0016491

GO:0016616

GO:0046872

GO:0051287

GO:1902031

HMNXSV003008110

Hs2.318977.1.S1_3p_at

ILMN_1675186

ILMN_2048636

M55905_at

PH_hs_0004315

TC18000180.hg

g12652790_3p_at

g187299_3p_a_at

Participates

as a member of

as a component of

ME2:Mg2+ [mitochondrial matrix] (Homo sapiens)

Inferred To

men-1 [mitochondrial matrix] (Caenorhabditis elegans)

Men [mitochondrial matrix] (Drosophila melanogaster)

LOC121108229 [mitochondrial matrix] (Gallus gallus)

Me2 [mitochondrial matrix] (Mus musculus)

Me2 [mitochondrial matrix] (Rattus norvegicus)

Dmel\CG7848 [mitochondrial matrix] (Drosophila melanogaster)

Homologues of ME2 [mitochondrial matrix] (Drosophila melanogaster)

ME2 [mitochondrial matrix] (Bos taurus)

ME2 [mitochondrial matrix] (Canis familiaris)

ME2 [mitochondrial matrix] (Sus scrofa)

Menl-1 [mitochondrial matrix] (Drosophila melanogaster)

Menl-2 [mitochondrial matrix] (Drosophila melanogaster)

Men-b [mitochondrial matrix] (Drosophila melanogaster)

me2 [mitochondrial matrix] (Danio rerio)

me2 [mitochondrial matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001161807.1, NP_002387.1

ENSEMBL

ENSP00000372384, ENSG00000082212, ENST00000382927, ENST00000321341, ENSP00000321070

OpenTargets

ENSG00000082212

GeneCards

ME2

HPA

ENSG00000082212-ME2

PRO

P23368

Pharos - Targets

P23368

GlyGen

P23368

HMDB Protein

HMDBP00862

PDB

1EFK, 1EFL, 1DO8, 1PJ3, 1GZ3, 1PJ4, 7XDE, 7BSJ, 7BSK, 1GZ4, 7XDF, 7BSL, 7XDG, 1PJ2, 9AYI, 1QR6, 1PJL

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989)	0.483	2