SLIT1 binds COL4A5

Stable Identifier
R-HSA-9010396
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SLIT1 binds COL4A5
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in zebrafish, SLIT1 binds to a type IV collagen COL4A5, which forms the basement membrane on the surface of the optical tectum. COL4A5 and HSPGs may act synergistically to anchor SLIT1 in the basement membrane. ROBO2 receptor is required for lamina-specific axon pathfinding of retinal ganglion cells in the optical tectum (Xiao et al. 2011).
Participants
Input
Output
Participates
as an event of
Inferred From
Slit1a binds Col4a5 (Danio rerio)
Authored
Orlic-Milacic, M  (2017-06-23)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-06-27)
Cite Us!