Slit1a binds Col4a5

Stable Identifier
R-DRE-9010417
Type
Reaction [binding]
Species
Danio rerio
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Slit1a binds Col4a5
In zebrafish, Slit1a (75% sequence identity with human SLIT1) binds to a type IV collagen Col4a5 (65% sequence identity with human Col4a5), which forms the basement membrane on the surface of the tectum. Col4a5 and Hspgs may act synergistically to anchor Slit1a in the basement membrane. Robo2 receptor is required for lamina-specific axon pathfinding of retinal ganglion cells in the tectum (Xiao et al. 2011).
Literature References
PubMed ID Title Journal Year
21729787 Assembly of lamina-specific neuronal connections by slit bound to type IV collagen

Baier, H, Xiao, T, Cole, GJ, Gosse, NJ, Staub, W, Robles, E

Cell 2011
Participants
Orthologous Events
Authored
Reviewed
Created
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