APP translocates from plasma membrane to endosome lumen

Stable Identifier
R-HSA-9010091
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endosome lumen, plasma membrane
ReviewStatus
5/5
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APP translocates from plasma membrane to endosome lumen
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
APP that does not get processed by alpha-secretase in the non-amyloidogenic pathway is internalised to endosomes for further processing (Baranello et al. 2015).
Literature References
PubMed ID Title Journal Year
25523424 Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

Baranello, RJ, Bharani, KL, Padmaraju, V, Chopra, N, Lahiri, DK, Greig, NH, Pappolla, MA, Sambamurti, K

Curr Alzheimer Res 2015
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as an event of
Authored
Jassal, B  (2017-06-26)
Reviewed
Meras-Rios, A  (2018-08-10)
Created
Jassal, B  (2017-06-26)
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