APP translocates from plasma membrane to endosome lumen

Stable Identifier
R-HSA-9010091
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

APP that does not get processed by alpha-secretase in the non-amyloidogenic pathway is internalised to endosomes for further processing (Baranello et al. 2015).

Literature References
PubMed ID Title Journal Year
25523424 Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease

Baranello, RJ, Bharani, KL, Padmaraju, V, Chopra, N, Lahiri, DK, Greig, NH, Pappolla, MA, Sambamurti, K

Curr Alzheimer Res 2015
Participants
Participant Of
Authored
Reviewed
Created
Cite Us!