RUNX2 binds SMURF1

Stable Identifier
Reaction [binding]
Homo sapiens
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SMURF1, an E3 ubiquitin ligase, binds to RUNX2 (Zhao et al. 2003). While the direct interaction was demonstrated in mouse cells, it was shown that in human cells RUNX2 stability is increased upon SMURF1 knockdown while RUNX2 ubiquitination is decreased (Yang et al. 2014).

Literature References
PubMed ID Title Journal Year
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Zhao, M, Qiao, M, Oyajobi, BO, Mundy, GR, Chen, D

J. Biol. Chem. 2003
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Yang, F, Xu, N, Li, D, Guan, L, He, Y, Zhang, Y, Lu, Q, Zhang, X

J Endod 2014
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