SMURF1, an E3 ubiquitin ligase, binds to RUNX2 (Zhao et al. 2003). While the direct interaction was demonstrated in mouse cells, it was shown that in human cells RUNX2 stability is increased upon SMURF1 knockdown while RUNX2 ubiquitination is decreased (Yang et al. 2014).
Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y
Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D
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