RUNX2 binds SMURF1

Stable Identifier
R-HSA-9009401
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX2 binds SMURF1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMURF1, an E3 ubiquitin ligase, binds to RUNX2 (Zhao et al. 2003). While the direct interaction was demonstrated in mouse cells, it was shown that in human cells RUNX2 stability is increased upon SMURF1 knockdown while RUNX2 ubiquitination is decreased (Yang et al. 2014).
Literature References
PubMed ID Title Journal Year
25260729 A feedback loop between RUNX2 and the E3 ligase SMURF1 in regulation of differentiation of human dental pulp stem cells

Guan, L, Yang, F, Lu, Q, Zhang, Y, Li, D, Zhang, X, Xu, N, He, Y

J Endod 2014
12738770 E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation

Oyajobi, BO, Qiao, M, Zhao, M, Mundy, GR, Chen, D

J. Biol. Chem. 2003
Participants
Input
Output
Participates
as an event of
Inferred From
Runx2 binds Smurf1 (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-17)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-17)
Cite Us!