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SMURF1 [cytosol]
Stable Identifier
R-HSA-975972
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
RUNX2 binds SMURF1 (Homo sapiens)
RUNX2:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
RUNX2:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
SMURF1/2 bind PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)
SMAD7:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 ubiquitinates RHOA (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCE7 SMURF1
Gene Names
SMURF1, KIAA1625
Chain
chain:1-757
Reference Genes
BioGPS Gene:57154 SMURF1
COSMIC (genes):SMURF1 SMURF1
CTD Gene:57154 SMURF1
dbSNP Gene:57154 SMURF1
ENSEMBL:ENSG00000198742 SMURF1
HGNC:16807 SMURF1
KEGG:hsa:57154 SMURF1
Monarch:57154 SMURF1
NCBI Gene:57154 SMURF1
OMIM:605568 SMURF1
UCSC:Q9HCE7 SMURF1
Reference Transcript
RefSeq:NM_181349.2 SMURF1
RefSeq:NM_001199847.1 SMURF1
RefSeq:NM_020429.2 SMURF1
Participates
as an output of
SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)
SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1 (Homo sapiens)
as an input of
RUNX2 binds SMURF1 (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
as a component of
RUNX2:SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Smad7:SMURF1 [cytosol] (Homo sapiens)
SMAD7:SMURF1 [cytosol] (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
as a member of
SMURF [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
Other forms of this molecule
SMURF1 [nucleoplasm]
Inferred To
Ghost homologue of SMURF1 [cytosol]
(Caenorhabditis elegans)
SMURF1 [cytosol]
(Bos taurus)
SMURF1 [cytosol]
(Canis familiaris)
SMURF1 [cytosol]
(Dictyostelium discoideum)
SMURF1 [cytosol]
(Gallus gallus)
SMURF1 [cytosol]
(Plasmodium falciparum)
SMURF1 [cytosol]
(Sus scrofa)
pub1 [cytosol]
(Schizosaccharomyces pombe)
RSP5 [cytosol]
(Saccharomyces cerevisiae)
Smurf [cytosol]
(Drosophila melanogaster)
pub3 [cytosol]
(Schizosaccharomyces pombe)
smurf1 [cytosol]
(Danio rerio)
smurf1 [cytosol]
(Xenopus tropicalis)
Smurf1 [cytosol]
(Mus musculus)
Smurf1 [cytosol]
(Rattus norvegicus)
pub2 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SMURF1 [cytosol]
(Dictyostelium discoideum)
Homologues of SMURF1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_851994.1
,
NP_065162.1
,
NP_001186776.1
ENSEMBL
ENST00000361368
,
ENSP00000355326
,
ENSP00000354621
,
ENST00000361125
,
ENSG00000198742
OpenTargets
ENSG00000198742
IntEnz
2.3.2.26
GeneCards
SMURF1
HPA
ENSG00000198742-SMURF1
PRO
Q9HCE7
Pharos - Targets
Q9HCE7
HMDB Protein
HMDBP09298
PDB
2LAZ
,
2LB1
,
3PYC
,
2LB0
,
2LTX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.645
6
UniProt:Q53GL0 PKHO1
0.623
2
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.593
5
UniProt:Q15797 SMAD1
4
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.573
2
UniProt:Q9Y5W3 KLF2
0.508
2
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