Studies in mice have shown that once HIVEP3 (SHN3, Schnurri-3) and WWP1 are bound to RUNX2, WWP1, an E3 ubiquitin ligase, polyubiquitinates RUNX2, targeting it for proteasome-mediated degradation. HIVEP3 overexpression in human embryonic kidney 293T cells leads to a dose-dependent decrease in RUNX2 protein levels (Jones et al. 2006).
ubiquitin protein ligase activity of RUNX2:HIVEP3:WWP1 [cytosol]
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