Wwp1 polyubiquitinates Runx2

Stable Identifier
R-MMU-9008077
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
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Wwp1 polyubiquitinates Runx2
Once a complex between Runx2, Hivep3 (Shn3, Schnurri-3) and Wwp1 is formed in mouse cells, Wwp1, an E3 ubiquitin ligase, polyubiquitinates Runx2 (Jones et al. 2006).
Literature References
PubMed ID Title Journal Year
16728642 Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3

Glimcher, LH, Oukka, M, Wein, MN, Hofstaetter, JG, Jones, DC, Glimcher, MJ

Science 2006
Participants
Input
Output
Catalyst Activity

ubiquitin protein ligase activity of Runx2:Hivep3:Wwp1 [cytosol]

Physical Entity
Runx2:Hivep3:Wwp1 [cytosol] (Mus musculus)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
WWP1 polyubiquitinates RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-07)
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