Reactome | IL21:IL21R:JAK1 binds IL2RG:JAK3

IL21:IL21R:JAK1 binds IL2RG:JAK3

Stable Identifier

R-HSA-9006844

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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Interleukin-21 receptor (IL21R, NILR) can bind Janus kinase 1 (JAK1) (Ozaki et al. 2000) but little or no signaling occurs (Asao et al. 2001) unless IL21R is combined with IL2RG, which is required for a fully signaling capable IL21 receptor complex (Ozaki et al. 2000, Asao et al. 2001, Habib et al. 2002). The heteromeric IL21 receptor complex can activate JAK1 and JAK3.

This is a black box event because the pre-association of IL21R with JAK1 and of IL2RG with JAK3 is inferred from the mechanism of IL2 signaling.

Literature References

PubMed ID	Title	Journal	Year
12093291	The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3 Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K	Biochemistry	2002
11016959	Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain Ozaki, K, Kikly, K, Michalovich, D, Young, PR, Leonard, WJ	Proc. Natl. Acad. Sci. U.S.A.	2000
11418623	Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K	J. Immunol.	2001