IL21:IL21R:JAK1 binds IL2RG:JAK3

Stable Identifier
R-HSA-9006844
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin-21 receptor (IL21R, NILR) can bind Janus kinase 1 (JAK1) (Ozaki et al. 2000) but little or no signaling occurs (Asao et al. 2001) unless IL21R is combined with IL2RG, which is required for a fully signaling capable IL21 receptor complex (Ozaki et al. 2000, Asao et al. 2001, Habib et al. 2002). The heteromeric IL21 receptor complex can activate JAK1 and JAK3.

This is a black box event because the pre-association of IL21R with JAK1 and of IL2RG with JAK3 is inferred from the mechanism of IL2 signaling.

Literature References
PubMed ID Title Journal Year
11016959 Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

Ozaki, K, Kikly, K, Michalovich, D, Young, PR, Leonard, WJ

Proc. Natl. Acad. Sci. U.S.A. 2000
12093291 The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3

Habib, T, Senadheera, S, Weinberg, K, Kaushansky, K

Biochemistry 2002
11418623 Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex

Asao, H, Okuyama, C, Kumaki, S, Ishii, N, Tsuchiya, S, Foster, D, Sugamura, K

J. Immunol. 2001
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