Reactome | JAK2 transphosphorylates and is activated in response to Erythropoietin

JAK2 transphosphorylates and is activated in response to Erythropoietin

Stable Identifier

R-HSA-9006332

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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JAK2 transphosphorylates and is activated in response to Erythropoietin

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Upon binding EPO, the EPOR dimer changes conformation, resulting in activation of JAK2 associated with box 1 and box 2 of the cytoplasmic domain of each EPOR (inferred from mouse homologs). One JAK2 transphosphorylates 12 tyrosine residues of the other JAK2 thereby activating JAK2 to phosphorylate EPOR and other substrates (Arcasoy et al. 1999, Watowich et al. 1999, Erickson-Miller et al. 2000, and inferred from mouse homologs).

Literature References

PubMed ID	Title	Journal	Year
9923445	A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation Arcasoy, MO, Harris, KW, Forget, BG	Exp. Hematol.	1999
11007921	Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: transient versus sustained proliferation Erickson-Miller, CL, Pelus, LM, Lord, KA	Stem Cells	2000
10498627	Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state Watowich, SS, Xie, X, Klingmüller, U, Kere, J, Lindlof, M, Berglund, S, de la Chapelle, A	Blood	1999

Participants

Input

Output

Participates

as an event of

Signaling by Erythropoietin (Homo sapiens)

Catalyst Activity

protein tyrosine kinase activity of EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane]

Physical Entity

EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane] (Homo sapiens)

Activity

protein tyrosine kinase activity (GO:0004713)

Inferred From

Jak2 transphosphorylates and is activated in response to Erythropoietin (Mus musculus)

Authored

May, B (2017-04-22)

Reviewed

McGraw, KL (2018-08-14)

Created

May, B (2017-05-13)

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