JAK2 transphosphorylates and is activated in response to Erythropoietin

Stable Identifier
R-HSA-9006332
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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JAK2 transphosphorylates and is activated in response to Erythropoietin
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Upon binding EPO, the EPOR dimer changes conformation, resulting in activation of JAK2 associated with box 1 and box 2 of the cytoplasmic domain of each EPOR (inferred from mouse homologs). One JAK2 transphosphorylates 12 tyrosine residues of the other JAK2 thereby activating JAK2 to phosphorylate EPOR and other substrates (Arcasoy et al. 1999, Watowich et al. 1999, Erickson-Miller et al. 2000, and inferred from mouse homologs).

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Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane]
Physical Entity
EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Jak2 transphosphorylates and is activated in response to Erythropoietin (Mus musculus)
Authored
May, B  (2017-04-22)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-05-13)