JAK2 transphosphorylates and is activated in response to Erythropoietin

Stable Identifier
Reaction [transition]
Homo sapiens
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Upon binding EPO, the EPOR dimer changes conformation, resulting in activation of JAK2 associated with box 1 and box 2 of the cytoplasmic domain of each EPOR (inferred from mouse homologs). One JAK2 transphosphorylates 12 tyrosine residues of the other JAK2 thereby activating JAK2 to phosphorylate EPOR and other substrates (Arcasoy et al. 1999, Watowich et al. 1999, Erickson-Miller et al. 2000, and inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
9923445 A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation

Forget, BG, Arcasoy, MO, Harris, KW

Exp. Hematol. 1999
11007921 Signaling induced by erythropoietin and stem cell factor in UT-7/Epo cells: transient versus sustained proliferation

Erickson-Miller, CL, Pelus, LM, Lord, KA

Stem Cells 2000
10498627 Erythropoietin receptor mutations associated with familial erythrocytosis cause hypersensitivity to erythropoietin in the heterozygous state

Watowich, SS, Berglund, S, de la Chapelle, A, Klingm├╝ller, U, Lindlof, M, Kere, J, Xie, X

Blood 1999
Catalyst Activity

protein tyrosine kinase activity of EPO:EPOR:JAK2:LYN:IRS2 [plasma membrane]

Inferred From
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