Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308

Stable Identifier
R-HSA-9005561
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308
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MECP2 R306C mutant, and possibly MECP2 R306H mutant, cannot be phosphorylated at threonine residue T308 by activated calcium-dependent protein kinases PKA and CaMK IV in response to neuronal activity (Ebert et al. 2013).
Literature References
PubMed ID Title Journal Year
23770587 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

Ebert, DH, Gabel, HW, Robinson, ND, Kastan, NR, Hu, LS, Cohen, S, Navarro, AJ, Lyst, MJ, Ekiert, R, Bird, AP, Greenberg, ME

Nature 2013
Participants
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Participates
as an event of
Catalyst Activity

calcium,diacylglycerol-dependent serine/threonine kinase activity of Active PRKACA,CaMK IV [nucleoplasm]

Physical Entity
Active PRKACA,CaMK IV [nucleoplasm] (Homo sapiens)
Activity
calcium,diacylglycerol-dependent serine/threonine kinase activity (GO:0004698)
Normal reaction
MECP2 is phosphorylated at T308 (Homo sapiens)
Functional status

Loss of function of MECP2 mutants R306C,(R306H) [nucleoplasm]

Normal Entity
Disease Entity
Status
Inferred From
Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308 (Mus musculus)
Disease
Name Identifier Synonyms
Rett syndrome DOID:1206 Rett's disorder, cerebroatrophic hyperammonemia
Cross References
Mondo
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-05-09)
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