Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308

Stable Identifier
R-HSA-9005561
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MECP2 R306C mutant, and possibly MECP2 R306H mutant, cannot be phosphorylated at threonine residue T308 by activated calcium-dependent protein kinases PKA and CaMK IV in response to neuronal activity (Ebert et al. 2013).

Literature References
PubMed ID Title Journal Year
23770587 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

Ebert, DH, Gabel, HW, Robinson, ND, Kastan, NR, Hu, LS, Cohen, S, Navarro, AJ, Lyst, MJ, Ekiert, R, Bird, AP, Greenberg, ME

Nature 2013
Participants
Participates
Catalyst Activity

calcium-dependent protein kinase activity of Active PRKACA,CaMK IV [nucleoplasm]

Normal reaction
Functional status

Loss of function of MECP2 mutants R306C,(R306H) [nucleoplasm]

Status
Inferred From
Disease
Name Identifier Synonyms
Rett syndrome DOID:1206 Rett's disorder, cerebroatrophic hyperammonemia
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