Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308

Stable Identifier
R-MMU-9005872
Type
Reaction [transition]
Species
Mus musculus
Compartment
Synonyms
Mecp2_e2 mutants R306C,(R306H) are not phosphorylated at T308
General
SVG |   | PPTX  | SBGN
Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308

Recombinant mouse mutant Mecp2 protein Mecp2_e2 R306C cannot be phosphorylated by recombinant mouse PKA C alpha (Prkaca) or recombinant active mouse CaMK IV (Ebert et al. 2013).

Literature References
PubMed ID Title Journal Year
23770587 Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR

Kastan, NR, Greenberg, ME, Ekiert, R, Bird, AP, Lyst, MJ, Hu, LS, Gabel, HW, Cohen, S, Navarro, AJ, Ebert, DH, Robinson, ND

Nature 2013
Participants
Catalyst Activity

calcium-dependent protein kinase activity of Active Prkaca,CaMKIV [nucleoplasm]

Normal reaction
Functional status

Loss of function of Mecp2 e2 R306C [nucleoplasm]

Status
Orthologous Events
Disease
Name Identifier Synonyms
Rett syndrome DOID:1206 Rett's disorder, cerebroatrophic hyperammonemia
Authored
Reviewed
Created
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