IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B

Stable Identifier
R-HSA-8985929
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
STAT1, STAT3 or STAT5 bind IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Signal transducer and activator of transcription 1-alpha/beta (STAT1), STAT3, STAT5A and STAT5B bind to the Interleukin-9:Interleukin-9 receptor (IL9:IL9R). Mutation of IL9R phosphorylated tyrosine-116 abolished activation of STAT1, STAT3 and STAT5 (Demoulin et al. 1996, Bauer et al. 1998). Other residues near this position are involved in determining which STAT binds to the receptor (Demoulin et al. 1999).

Literature References
PubMed ID Title Journal Year
9535918 Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis

Bauer, JH, Liu, KD, You, Y, Lai, SY, Goldsmith, MA

J. Biol. Chem. 1998
8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

Demoulin, JB, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, Renauld, JC

Mol. Cell. Biol. 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created