Reactome | IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B

IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B

Stable Identifier

R-HSA-8985929

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

STAT1, STAT3 or STAT5 bind IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3

ReviewStatus

5/5

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IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B

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Signal transducer and activator of transcription 1-alpha/beta (STAT1), STAT3, STAT5A and STAT5B bind to the Interleukin-9:Interleukin-9 receptor (IL9:IL9R). Mutation of IL9R phosphorylated tyrosine-407 abolished activation of STAT1, STAT3 and STAT5 (Demoulin et al. 1996, Bauer et al. 1998). Other residues near this position are involved in determining which STAT binds to the receptor (Demoulin et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
8756628	A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Demoulin, JB, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, Renauld, JC	Mol. Cell. Biol.	1996
9535918	Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis Bauer, JH, Liu, KD, You, Y, Lai, SY, Goldsmith, MA	J. Biol. Chem.	1998