Reactome | IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3

IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3

Stable Identifier

R-HSA-8985914

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3

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Tyrosine-protein kinase JAK3 (JAK3) is believed to become phosphorylated after IL9:IL9R interaction as this is thought to be a mechanism common to all receptors that incorporate IL2RG (Haan et al. 2011). There is no clear evidence for JAK1 phosphorylation by IL9 treatment, except in pathological states (Hornakova et al. 2009, Gordon et al. 2010).

This is a black box event because phosphorylation of JAK3 is inferred from the signaling mechanism of the related IL2 receptor (Johnston et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
8756628	A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Uyttenhove, C, Demoulin, JB, Van Snick, J, Van Roost, E, Donckers, D, DeLestré, B, Renauld, JC	Mol. Cell. Biol.	1996
8022485	Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2 Ortaldo, JR, Shibuya, K, Blake, TB, McVicar, DW, Kawamura, M, Chen, YQ, Johnston, JA, O'Shea, JJ, Kirken, RA	Nature	1994
18250158	Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity Frost, JA, Kirken, RA, Cheng, H, Ross, JA	Mol. Cell. Biol.	2008
21439476	Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors Zerwes, HG, Drückes, P, Thoma, G, Kapp, M, Behrmann, I, Rolvering, C, Raulf, F, Haan, C	Chem. Biol.	2011