Reactome | p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3

p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3

Stable Identifier

R-HSA-8985900

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 dissociates from p-Y-STAT1, p-Y705-STAT3, p-STAT5

ReviewStatus

5/5

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p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3

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Signal transducer and activator of transcription 1-alpha/beta (STAT1), STAT3 and STAT5A/STAT5B (collectively termed STAT5) are believed to dissociate from the Interleukin 9:Interleukin 9 receptor complex.

STAT1 (Demoulin et al, 1996), STAT3 (Yamasaki et al. 2010) and STAT5 (Demoulin et al. 2000) have been identified as parts of complexes associated with DNA in the nucleus following IL9 stimulation. All 3 STATs are believed to follow the standard model for STAT signaling, namely dissociation from the receptor complex, dimerization and translocation to the nucleus (Demoulin et al. 2000, Demoulin et al. 2000, Levy & Darnell 2002).

Literature References

PubMed ID	Title	Journal	Year
8756628	A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9 Demoulin, JB, Uyttenhove, C, Van Roost, E, DeLestré, B, Donckers, D, Van Snick, J, Renauld, JC	Mol. Cell. Biol.	1996
10919676	STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells Demoulin, JB, Uyttenhove, C, Lejeune, D, Mui, A, Groner, B, Renauld, JC	Cancer Res.	2000
11306517	Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor Demoulin, JB, Van Snick, J, Renauld, JC	Cell Growth Differ.	2001
20169197	IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells Yamasaki, A, Saleh, A, Koussih, L, Muro, S, Halayko, AJ, Gounni, AS	PLoS ONE	2010