p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3

Stable Identifier
Reaction [omitted]
Homo sapiens
IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3 dissociates from p-Y-STAT1, p-Y705-STAT3, p-STAT5
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Signal transducer and activator of transcription 1-alpha/beta (STAT1), STAT3 and STAT5A/STAT5B (collectively termed STAT5) are believed to dissociate from the Interleukin 9:Interleukin 9 receptor complex.

STAT1 (Demoulin et al, 1996), STAT3 (Yamasaki et al. 2010) and STAT5 (Demoulin et al. 2000) have been identified as parts of complexes associated with DNA in the nucleus following IL9 stimulation. All 3 STATs are believed to follow the standard model for STAT signaling, namely dissociation from the receptor complex, dimerization and translocation to the nucleus (Demoulin et al. 2000, Demoulin et al. 2000, Levy & Darnell 2002).

Literature References
PubMed ID Title Journal Year
8756628 A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

Uyttenhove, C, Demoulin, JB, Van Snick, J, Van Roost, E, Donckers, D, DeLestré, B, Renauld, JC

Mol. Cell. Biol. 1996
10919676 STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells

Uyttenhove, C, Groner, B, Demoulin, JB, Renauld, JC, Lejeune, D, Mui, A

Cancer Res. 2000
11306517 Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor

Demoulin, JB, Van Snick, J, Renauld, JC

Cell Growth Differ. 2001
20169197 IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells

Koussih, L, Yamasaki, A, Halayko, AJ, Saleh, A, Muro, S, Gounni, AS

PLoS ONE 2010
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