NCK2 binds to ROBO1,(ROBO2)

Stable Identifier
R-HSA-8985812
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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NCK2 binds to ROBO1,(ROBO2)
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Based on mouse experiments, SLIT1-activated ROBO receptors ROBO1 and/or ROBO2 bind to NCK2. The interaction involves three SH3 domains of NCK2 and the PxxP-rich region between CC2 and CC3 motifs in the cytoplasmic domain of ROBO. While NCK1 can also associate with ROBO receptors, only NCK2 is implicated in SLIT1-induced cortical dendrite branching (Round and Sun 2011).
Literature References
PubMed ID Title Journal Year
21600986 The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology

Sun, H, Round, JE

Mol. Cell. Neurosci. 2011
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Inferred From
Nck2 binds to Robo1,(Robo2) (Mus musculus)
Authored
Orlic-Milacic, M  (2017-06-26)
Reviewed
Jaworski, A  (2017-07-31)
Created
Orlic-Milacic, M  (2017-04-20)
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