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Regulation of cortical dendrite branching
Stable Identifier
R-HSA-8985801
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of cortical dendrite branching (Homo sapiens)
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Besides being involved in axon repulsion during neuronal system development, SLIT-ROBO signaling is also involved in dendrite branching. Based on studies in mice, SLIT1 triggers cortical dendrite branching by activating receptors ROBO1 and/or ROBO2. ROBO effector NCK2 is needed for SLIT1-mediated dendrite branching (Round and Sun 2011).
Literature References
PubMed ID
Title
Journal
Year
21600986
The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology
Sun, H
,
Round, JE
Mol. Cell. Neurosci.
2011
Participants
Events
SLIT1 binds ROBO1,(ROBO2)
(Homo sapiens)
NCK2 binds to ROBO1,(ROBO2)
(Homo sapiens)
Participates
as an event of
Signaling by ROBO receptors (Homo sapiens)
Authored
Orlic-Milacic, M (2017-06-26)
Reviewed
Jaworski, A (2017-07-31)
Created
Orlic-Milacic, M (2017-04-20)
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