PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated

Stable Identifier
Reaction [transition]
Homo sapiens
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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins (G-proteins) that have alpha, beta and gamma subunits. Upon activation, the alpha subunit of G-proteins dissociates from beta-gamma and the both are then free to regulate downstream effectors. Serine/threonine-protein kinase PAK 1 binds with Rho guanine nucleotide exchange factor 6 (ARHGEF6, PIX-Alpha) in the cytosol and is subsequently translocated by the G-protein beta-gamma complex to the plasma membrane. Here, ARHGEF6 activates the GTPase Cell division control protein 42 homolog (CDC42) by acting as a GEF. Upon activation, CDC42 facilitates the activation of PAK1 by exposing its catalytic domains. PAK1 is a signalling entity playing a key role in cytoskeleton dynamics, cell adhesion, migration, proliferation, apoptosis, mitosis, and vesicle-mediated transport processes.

Literature References
PubMed ID Title Journal Year
12887923 Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42

Wu, Y, Li, Z, Mo, Z, Smrcka, AV, Huang, CK, Liu, B, Lu, W, Wu, G, Wu, D, Li, L, Liu, M, Hannigan, M

Cell 2003
Orthologous Events
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