E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2

Stable Identifier
R-HSA-8964513
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2
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Transcription of the E2F1 gene is directly inhibited by the DREAM complex (Litovchick et al. 2007). E2F1 transcription is also directly inhibited by the complex of HDAC1 and RBL1 (p107) or RBL2 (p130) (Rayman et al. 2002).
Literature References
PubMed ID Title Journal Year
11959842 E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Rayman, JB, Takahashi, Y, Indjeian, VB, Dannenberg, JH, Catchpole, S, Watson, RJ, te Riele, H, Dynlacht, BD

Genes Dev 2002
17531812 Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

Litovchick, L, Sadasivam, S, Florens, LA, Zhu, X, Swanson, SK, Velmurugan, S, Chen, R, Washburn, MP, Liu, XS, DeCaprio, JA

Mol Cell 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm] (Homo sapiens)
Active Unit
HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm]
Regulator
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
Active Unit
DREAM complex [nucleoplasm]
Inferred From
E2f1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1 (Mus musculus)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2017-02-17)
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