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DREAM complex
Stable Identifier
R-HSA-1362264
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC25A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the CDC6 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the E2F1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the PCNA gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the RBL1 gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex binds the TOP2A gene promoter (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex:RBL1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
TOP2A gene gene expression is repressed by the DREAM complex (Homo sapiens)
DREAM complex:TOP2A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
DREAM complex:E2F1 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
p130 (RBL2) associates with MuvB to form DREAM complex (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
Activation of E2F1 target genes at G1/S (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:CDC6 gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
DREAM complex:PCNA gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
DREAM complex:CDC25A gene [nucleoplasm] (Homo sapiens)
DREAM complex [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
17531812
Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
Mol Cell
2007
Participants
components
p-MuvB complex [nucleoplasm] (Homo sapiens)
RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Participant Of
input
DREAM complex binds the CDC25A gene promoter
DREAM complex binds the CDC6 gene promoter
DREAM complex binds the E2F1 gene promoter
DREAM complex binds the PCNA gene promoter
DREAM complex binds the RBL1 gene promoter
DREAM complex binds the TOP2A gene promoter
hasComponent
DREAM complex:CDC25A gene [nucleoplasm]
DREAM complex:CDC6 gene [nucleoplasm]
DREAM complex:E2F1 gene [nucleoplasm]
DREAM complex:PCNA gene [nucleoplasm]
DREAM complex:RBL1 gene [nucleoplasm]
DREAM complex:TOP2A gene [nucleoplasm]
output
p130 (RBL2) associates with MuvB to form DREAM complex
This entity regulates
Negative Regulation
'DREAM complex [nucleoplasm]' negatively regulates 'Transcription of E2F targets under negative control by DREAM complex'
Inferred To
DREAM complex [nucleoplasm] (Arabidopsis thaliana)
DREAM complex [nucleoplasm] (Bos taurus)
DREAM complex [nucleoplasm] (Canis familiaris)
DREAM complex [nucleoplasm] (Danio rerio)
DREAM complex [nucleoplasm] (Drosophila melanogaster)
DREAM complex [nucleoplasm] (Gallus gallus)
DREAM complex [nucleoplasm] (Mus musculus)
DREAM complex [nucleoplasm] (Oryza sativa)
DREAM complex [nucleoplasm] (Rattus norvegicus)
DREAM complex [nucleoplasm] (Sus scrofa)
DREAM complex [nucleoplasm] (Taeniopygia guttata)
DREAM complex [nucleoplasm] (Xenopus tropicalis)
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