G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC

Stable Identifier
R-HSA-8964242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC
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G-Protein Coupled Receptors sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the alpha subunit of the G protein (GNAI) can directly bind to SRC. In the presence of active GNAI, SRC can autophosphorylate the 419-tyrosine residue, which leads to the subsequent activation of SRC. Physiologically, the SRC family have implications in cell growth and cancer.
Literature References
PubMed ID Title Journal Year
11007482 Src tyrosine kinase is a novel direct effector of G proteins

Ma, YC, Huang, J, Ali, S, Lowry, W, Huang, XY

Cell 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of G alpha (i):GTP:SRC-1 [plasma membrane]

Physical Entity
G alpha (i):GTP:SRC-1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Bos taurus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Caenorhabditis elegans)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Canis familiaris)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Danio rerio)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Gallus gallus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Mus musculus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Rattus norvegicus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Sus scrofa)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Xenopus tropicalis)
Authored
Varusai, TM  (2017-07-27)
Reviewed
Huang, X  (2018-09-13)
Created
Varusai, TM  (2017-02-16)
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