G alpha (i) signalling events

Stable Identifier
R-HSA-418594
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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G alpha (i) signalling events
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The classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase (Dessauer C W et al. 2002). Decreased production of cAMP from ATP results in decreased activity of cAMP-dependent protein kinases. Other functions of G alpha (i) includes activation of the protein tyrosine kinase c-Src (Ma Y C et al. 2000). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (i) (Soundararajan et al. 2008).
Literature References
PubMed ID Title Journal Year
9278091 Role of subunit diversity in signaling by heterotrimeric G proteins

Hildebrandt, JD

Biochem Pharmacol 1997
3113327 G proteins: transducers of receptor-generated signals

Gilman, AG

Annu Rev Biochem 1987
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Orthologous Events
G alpha (i) signalling events (Bos taurus)
G alpha (i) signalling events (Caenorhabditis elegans)
G alpha (i) signalling events (Canis familiaris)
G alpha (i) signalling events (Danio rerio)
G alpha (i) signalling events (Dictyostelium discoideum)
G alpha (i) signalling events (Drosophila melanogaster)
G alpha (i) signalling events (Gallus gallus)
G alpha (i) signalling events (Mus musculus)
G alpha (i) signalling events (Plasmodium falciparum)
G alpha (i) signalling events (Rattus norvegicus)
G alpha (i) signalling events (Saccharomyces cerevisiae)
G alpha (i) signalling events (Schizosaccharomyces pombe)
G alpha (i) signalling events (Sus scrofa)
G alpha (i) signalling events (Xenopus tropicalis)
Authored
Jupe, S  (2009-05-01)
Reviewed
Akkerman, JW  (2009-06-03)
Created
Jupe, S  (2009-04-24)
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