POLA1 gene transcription is stimulated by E2F1

Stable Identifier
R-HSA-8961632
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
POLA1 gene transcription is stimulated by E2F1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F1 binds to E2F binding sites in the promoter of the POLA1 gene, stimulating POLA1 transcription. POLA1 encodes the catalytic subunit p180 of the DNA polymerase alpha (DeGregori et al. 1995, Giangrande et al. 2004). Activation of POLA1 by E2F1 has also been demonstrated in Drosophila (Ohtani and Nevins 1994).

Literature References
PubMed ID Title Journal Year
15014447 Combinatorial gene control involving E2F and E Box family members

Laakso, N, Nevins, JR, Rempel, RE, Zhu, W, Giangrande, PH

EMBO J. 2004
8114698 Functional properties of a Drosophila homolog of the E2F1 gene

Nevins, JR, Ohtani, K

Mol Cell Biol 1994
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

Nevins, JR, DeGregori, J, Kowalik, T

Mol Cell Biol 1995
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
Active Unit
E2F1:TFDP1,TFDP2 [nucleoplasm]
Authored
Gopinathrao, G  (2004-06-16)
Reviewed
Bosco, G  (2004-06-16)
Created
Orlic-Milacic, M  (2017-02-04)
Cite Us!