POLA1 gene transcription is stimulated by E2F1

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Reaction [omitted]
Homo sapiens
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E2F1 binds to E2F binding sites in the promoter of the POLA1 gene, stimulating POLA1 transcription. POLA1 encodes the catalytic subunit p180 of the DNA polymerase alpha (DeGregori et al. 1995, Giangrande et al. 2004). Activation of POLA1 by E2F1 has also been demonstrated in Drosophila (Ohtani and Nevins 1994).

Literature References
PubMed ID Title Journal Year
8114698 Functional properties of a Drosophila homolog of the E2F1 gene

Ohtani, K, Nevins, JR

Mol Cell Biol 1994
15014447 Combinatorial gene control involving E2F and E Box family members

Giangrande, PH, Zhu, W, Rempel, RE, Laakso, N, Nevins, JR

EMBO J. 2004
7623816 Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

DeGregori, J, Kowalik, T, Nevins, JR

Mol Cell Biol 1995
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