SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-8959781
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix, mitochondrial inner membrane
ReviewStatus
5/5
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SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix
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Members of the solute carrier family 25 (SLC25) can transport carboxylates, amino acids, nucleotides and cofactors across the inner mitochondrial membrane, thereby connecting cytosolic and matrix functions. The main physiological role of mitochondrial basic amino acids transporter (SLC25A29) is to carry basic amino acids into the mitochondrion. It transports arginine (L-Arg), lysine (L-Lys), homoarginine (homoArg), methylarginine (methylArg) and, to a much lesser extent, ornithine (L-Orn) and histidine (L-His) (Porcelli et al. 2014).
Literature References
PubMed ID Title Journal Year
24652292 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids

Porcelli, V, Fiermonte, G, Longo, A, Palmieri, F

J. Biol. Chem. 2014
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Catalyst Activity

basic amino acid transmembrane transporter activity of SLC25A29 [mitochondrial inner membrane]

Physical Entity
SLC25A29 [mitochondrial inner membrane] (Homo sapiens)
Activity
basic amino acid transmembrane transporter activity (GO:0015174)
Orthologous Events
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Bos taurus)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Caenorhabditis elegans)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Canis familiaris)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Danio rerio)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Drosophila melanogaster)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Gallus gallus)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Mus musculus)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Rattus norvegicus)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)
SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2017-01-31)
Reviewed
D'Eustachio, P  (2017-02-06)
Created
Jassal, B  (2017-01-31)
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