SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix

Stable Identifier
R-HSA-8959781
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Members of the solute carrier family 25 (SLC25) can transport carboxylates, amino acids, nucleotides and cofactors across the inner mitochondrial membrane, thereby connecting cytosolic and matrix functions. The main physiological role of mitochondrial basic amino acids transporter (SLC25A29) is to carry basic amino acids into the mitochondrion. It transports arginine (L-Arg), lysine (L-Lys), homoarginine (homoArg), methylarginine (methylArg) and, to a much lesser extent, ornithine (L-Orn) and histidine (L-His) (Porcelli et al. 2014).

Literature References
PubMed ID Title Journal Year
24652292 The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids

Porcelli, V, Fiermonte, G, Longo, A, Palmieri, F

J. Biol. Chem. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
basic amino acid transmembrane transporter activity of SLC25A29 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!