RUNX1 binds the SOCS4 gene

Stable Identifier
R-HSA-8955822
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX1 binds the SOCS4 gene
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Based on studies in mouse keratinocytes, RUNX1, presumably in complex with CBFB, binds the SOCS4 gene (Scheitz et al. 2012). Runx binding elements are found in the promoter region and enhancer elements downstream of the mouse Socs4 gen. In the human SOCS4 gene, Runx binding elements can be found in the first intron and downstream of the SOCS4 gene.
Literature References
PubMed ID Title Journal Year
23034403 Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

Lee, TS, Tumbar, T, McDermitt, DJ, Scheitz, CJ

EMBO J. 2012
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Runx1 binds the Socs4 gene (Mus musculus)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-13)
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