Activated Signal transducer and activator of transcription 4 (STAT4) and STAT3 are released as subunits after Interleukin-23 (IL23) binds the Interleukin-23 heterodimeric receptor (Parham et al. 2002, Silvanesan et al. 2016). This is a Black box event since the exact mechanisms of STAT3 and STAT4 binding, phosphorylation, dissociation and dimerization are unknown.
Sivanesan, D, Beauchamp, C, Quinou, C, Lee, J, Lesage, S, Chemtob, S, Rioux, JD, Michnick, SW
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