p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor

Stable Identifier
R-HSA-8952823
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Activated Signal transducer and activator of transcription 4 (STAT4) and STAT3 are released as subunits after Interleukin-23 (IL23) binds the Interleukin-23 heterodimeric receptor (Parham et al. 2002, Silvanesan et al. 2016).
This is a Black box event since the exact mechanisms of STAT3 and STAT4 binding, phosphorylation, dissociation and dimerization are unknown.

Literature References
PubMed ID Title Journal Year
26887945 IL23R (Interleukin 23 Receptor) Variants Protective against Inflammatory Bowel Diseases (IBD) Display Loss of Function due to Impaired Protein Stability and Intracellular Trafficking

Sivanesan, D, Beauchamp, C, Quinou, C, Lee, J, Lesage, S, Chemtob, S, Rioux, JD, Michnick, SW

J. Biol. Chem. 2016
Participants
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