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IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2
Stable Identifier
R-HSA-8950186
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-23 signaling (Homo sapiens)
IL23R in IL23:IL23 receptor complex is phosphorylated (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
STAT4 binds p-Y-IL23R in IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3:STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane] (Homo sapiens)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
23673666
Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor
J. Biol. Chem.
2013
27193299
Defining the functional binding sites of interleukin 12 receptor ?1 and interleukin 23 receptor to Janus kinases
Mol. Biol. Cell
2016
Participants
components
IL12B:IL23A [extracellular region] (Homo sapiens)
IL12RB1:TYK2 [plasma membrane] (Homo sapiens)
p-Y-IL23R:p-JAK2 [plasma membrane] (Homo sapiens)
Participant Of
input
STAT3 binds to p-Y-IL23R in IL23:IL23 receptor
hasComponent
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:p-Y705-STAT3:p-Y693-STAT4 [plasma membrane]
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2:STAT3 [plasma membrane]
output
IL23R in IL23:IL23 receptor complex is phosphorylated
p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor
Inferred From
Il12b:Il23a:Il12rb1:p-Y-Tyk2:p-Y542-Il23r,p-Y626-Il23r,p-Il23r:p-Jak2 [plasma membrane] (Mus musculus)
Inferred To
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Bos taurus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Canis familiaris)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Danio rerio)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Gallus gallus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Mus musculus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Rattus norvegicus)
IL23A:IL12B:IL12RB1:p-TYK2:p-Y-IL23R:p-JAK2 [plasma membrane] (Sus scrofa)
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