EP300 acetylates RUNX3

Stable Identifier
Reaction [transition]
Homo sapiens
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EP300 (p300) histone acetyltransferase acetylates RUNX3 on lysine residues K94 and K171 (Lee et al. 2013), and probably other lysines (Jin et al. 2004). EP300-mediated acetylation of RUNX3 is positively regulated by TGF-beta treatment. Besides increasing the transcriptional activity of RUNX3, EP300-mediated acetylation also increases the half-life of RUNX3, as it interferes with SMURF-mediated ubiquitination and subsequent degradation of RUNX3 (Jin et al. 2004).

Literature References
PubMed ID Title Journal Year
24229708 Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma

Lee, JW, Lee, YS, Chuang, LS, Kim, JH, Bae, SC, Jang, JW, Ito, Y, Suh, JW, Chi, XZ, Chung, JH, Choi, BS, Lee, OJ, Li, YH, Kim, EG, Kim, DM, Lee, YM, Kim, MK

Cancer Cell 2013
15138260 Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

Jeon, EJ, Jin, YH, Lee, YH, Li, QL, Lee, KY, Bae, SC, Kim, WJ, Choi, JK

J. Biol. Chem. 2004
Catalyst Activity

peptide-lysine-N-acetyltransferase activity of RUNX3:CBFB:EP300 [nucleoplasm]

This event is regulated
Orthologous Events
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