Reactome | EP300 acetylates RUNX3

EP300 acetylates RUNX3

Stable Identifier

R-HSA-8951966

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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EP300 (p300) histone acetyltransferase acetylates RUNX3 on lysine residues K94 and K171 (Lee et al. 2013), and probably other lysines (Jin et al. 2004). EP300-mediated acetylation of RUNX3 is positively regulated by TGF-beta treatment. Besides increasing the transcriptional activity of RUNX3, EP300-mediated acetylation also increases the half-life of RUNX3, as it interferes with SMURF-mediated ubiquitination and subsequent degradation of RUNX3 (Jin et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
24229708	Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma Lee, JW, Lee, YS, Chuang, LS, Kim, JH, Bae, SC, Jang, JW, Ito, Y, Suh, JW, Chi, XZ, Chung, JH, Choi, BS, Lee, OJ, Li, YH, Kim, EG, Kim, DM, Lee, YM, Kim, MK	Cancer Cell	2013
15138260	Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation Jeon, EJ, Jin, YH, Lee, YH, Li, QL, Lee, KY, Bae, SC, Kim, WJ, Choi, JK	J. Biol. Chem.	2004