Reactome | p-Y800-IL12RB2 [plasma membrane]

p-Y800-IL12RB2 [plasma membrane]

Stable Identifier

R-HSA-8950376

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Literature References

PubMed ID	Title	Journal	Year
10415122	Direct interaction of STAT4 with the IL-12 receptor Yao, BB, Faltynek, CR, Surowy, CS, Niu, P	Arch. Biochem. Biophys.	1999

External Reference Information

External Reference

UniProt:Q99665 IL12RB2

Gene Names

IL12RB2

Chain

signal peptide:1-23, chain:24-862

Reference Genes

BioGPS Gene:3595 IL12RB2

COSMIC (genes):IL12RB2 IL12RB2

CTD Gene:3595 IL12RB2

dbSNP Gene:3595 IL12RB2

ENSEMBL:ENSG00000081985 IL12RB2

HGNC:5972 IL12RB2

KEGG:hsa:3595 IL12RB2

Monarch:3595 IL12RB2

NCBI Gene:3595 IL12RB2

OMIM:601642 IL12RB2

UCSC:Q99665 IL12RB2

Reference Transcript

Other Identifiers

11737427_at

11748377_a_at

11749285_a_at

11755863_a_at

1534_at

16665901

206999_PM_at

206999_at

2340967

2340968

2340969

2340970

2340971

2340972

2340974

2340975

2340976

2340978

2340984

2340986

2340987

2340988

2340989

2340990

2340991

2340992

2340995

2340996

2340997

2340998

2341000

2341001

2341002

2341003

2341004

2341005

2341006

2341007

2341008

2341009

2341010

2341011

3595

7902205

A_14_P102512

A_23_P72077

GO:0004896

GO:0005515

GO:0005886

GO:0007166

GO:0008284

GO:0009897

GO:0015026

GO:0016020

GO:0019221

GO:0019901

GO:0019955

GO:0032496

GO:0032729

GO:0034097

GO:0035722

GO:0043235

GO:0060089

HMNXSV003020127

HMNXSV003041205

ILMN_1761921

PH_hs_0024954

TC01000741.hg

TC01004455.hg

U64198_at

g4504642_3p_at

Participates

as a component of

p-Y800-IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

IL12RB2 [plasma membrane]

Inferred To

phospho-il12rb2 [plasma membrane] (Xenopus tropicalis)

phospho-p-Y800-IL12RB2 [plasma membrane] (Gallus gallus)

phospho-Il12rb2 [plasma membrane] (Mus musculus)

phospho-Il12rb2 [plasma membrane] (Rattus norvegicus)

phospho-IL12RB2 [plasma membrane] (Bos taurus)

phospho-IL12RB2 [plasma membrane] (Canis familiaris)

phospho-IL12RB2 [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 800

Coordinate

800

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

Guide to Pharmacology - Targets

1716

OpenTargets

ENSG00000081985

ENSEMBL

ENST00000544434, ENSP00000501329, ENSP00000442443, ENSP00000497959, ENST00000648487, ENSP00000512854, ENSG00000081985, ENSP00000262345, ENST00000696757, ENST00000262345, ENST00000674203, ENSP00000360039, ENST00000371000

HPA

ENSG00000081985-IL12RB2

GeneCards

IL12RB2

PRO

Q99665

Pharos - Targets

Q99665

GlyGen

Q99665

PDB

8YI7, 8XRP

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14765 STAT4	4	p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.527	2